天然姜黄素的纯化和分子与晶体结构研究.pdf

2006, Vol. 27, No. 03 27 1 2 3 1 1 2 1 索全伶 ，黄延春 ，翁林红 ，贺文智 ，李春萍 ，李云霞 ，洪海龙 (1.内蒙古工业大学化工学院，内蒙古 呼和浩特 010062；2.内蒙古师范大学化学与环境科学学院， 内蒙古 呼和浩特 010022；3.复旦大学化学院，上海 200433) ：采用萃取法、柱层析法和重结晶法对产自四川省双流县的姜黄中的姜黄素进行了分离和纯化，利用IR， 1 13 UV，MS， HNMR， CNMR 和 X-ray 单晶衍射等测试手段对姜黄素的分子与晶体结构进行了表征，证实了姜 黄素的晶体结构属于单斜晶系，P2/n空间群。晶胞参数为：a=1.2695(3)nm，b=0.72075(16)nm，c=1.9960(4)nm， γ α=90°，β=95.098°， =90°，每个晶胞中含有四个姜黄素的分子。姜黄素的分子为非线型结构，呈现出酮 式- 烯醇式互变异构现象。 ：姜黄素；姜黄；分离与纯化；表征；分子结构 Study on Purification and Molecular Crystal Structure of Natural Curcumin 1 2 3 1 1 SUO Quan-ling ，HUANG Yan-chun ，WENG Lin-hong ，HE Wen-zhi ，LI Chun-ping ， LI Yun-xia2，HONG Hai-long1 (1.College of Chemical Engineering, Inner Mongolia University of Technology, Hohhot 010062, China； 2.College of Chemical and Environmental Science, Inner Mongolia Normal University, Hohhot 010022, China； 3.College of Chemistry, Fudan University, Shanghai 200433, China) Abstract ：A single crystal of curcumin was obtained from the turmeric of Shuangliu County of Sichuan Province, China by using separation and purification technique of solvent extraction, column chromatography and recrystallization etc. The molecular and 1 13 crystal structure of curcumin were identified by IR, UV, MS, HNMR, CNMR and X-ray single crystal diffraction. Curcumin crystal belongs to monoclinic with P2/n space group. The unit cell data are: a = 1.2695(3)nm, b = 0.72075(16) nm, c=1.9960 γ (