甘氨双唑钠（CMNa）对食管癌放射治疗增敏作用的临床观察.pdfVIP

第22卷 第6期 内蒙古民族大学学报(自然科学版) Vo1．22 NO．6 2007年12月 Journal of Inner Mongolia University for Nationalities Dec．20o7 甘氨双唑钠(CMNa)对食管癌 放射治疗增敏作用的临床观察 孙桂丽 ，任志红2，韩忠发3 (1．内蒙古民族大学附属医院肿瘤科，内蒙古通辽 028000；2．通辽市科尔沁区健康教育所，内蒙古通辽 028000； 3．木里图中心卫生院，内蒙古 木里图 028024) [摘 要]目的：初步评价甘氨双唑钠的放射增敏作用及其安全性．方法：各期食管癌病人65例，均符合入组 条件并有病理证实，随机分为治疗组和对照组．治疗组病人常规放疗同时使用CMNa 800mg／m 用100 ml生 理盐水稀释静点，每周3次，连续用至放疗结束．对照组用安慰剂加生理盐水．结果：治疗组的CR率高于对照 组(PO．05)．治疗组病人治疗达到PR和CR时的中位照射剂量均低于对照组．但由于病例数少。未观察到 统计学差异．结论：CMN．对食管癌有良好的放射治疗增敏作用，远期效果及安全性有待进一步的随诊观察． [关键词]放射增敏剂 ；甘氨双唑钠；安全性；有效性 [中图分类号)R735．1 [文献标识码】A [文章编号】1671—0185(2007)06—0665—02 The Cinical Study of CMNa on Radi0sensitiVity—enhanced Effect Treating Esophageal Cancer SUN Gui—li。，REN Zhi—hon82，HAN Zhong—fa3 (1．Affdiated Hospital。Inner Mongolia University for Nationalities。Tongliao 028000。China； 2．Kerchin District Health Education Office。Tongliao 028000，China； 3．Mulitu Central Health Centre。Mulitu 028024，China) Abstract：Objective：To evaluate the radiosensitivity—‘enhanced function and safety of CMNa pre— liminarily．Methods：65 patients with esophageal cancer were divided into two groups randomly： treatment group(A Group)and control group(B Group)．The patients in treatment group were in— fused with CMNa 800mg／m2 via intravenous dripx diluted by lOOml physiological saline，triple a week during whole treatment period．The patients in eontol group received placebo and normal saline．Results：The CR rate of A Group WaS significantly higher than that of B Group(P0． 05)．The median dose of A Group WaS lower than that of B Group before the PR and CR were