职业接触灭蚁药物人群的肝功能损伤.pdfVIP

环境与职业医学2007年12月第24卷第6期 J Environ Oeeup Med，Dec．2007 Vo1．24 No．6 ·603· 文章编号：1006．3617(2007)06—0603—03 中图分类号：R135 文献标识码：A 【论著】 职业接触灭蚁药物人群的肝功能损伤 朱宝立，班永宏，陈敏 摘要： [目的]探讨职业性接触氯丹、含砷化合物灭蚁药物对作业人员肝功能水平的影响。 [方法]对作业人 员进行血清丙氨酸转氨酶(AIJT)、天门冬氨酸转氨酶(AST)、y一谷氨酰转移酶(7-GT)、碱性磷酸酶(ALP)、乳酸脱氢酶 (LDH)、甘胆酸(CG)、氯丹和尿液砷水平进行了检测分析。并对工龄、吸烟、饮酒和体内毒物的浓度对肝功能各项指标 的影响进行统计学分析。 [结果]职业接触灭蚁药物使血清y—GT、LDH和CG水平增高(尸0．05)，并与接触工龄相关； 饮酒能加重含砷和氯丹类灭蚁药物对职业人群肝脏的损伤作用(尸0．05)，使血清7-GT、LDH和CG水平显著增高，吸烟 对接触含砷或氯丹类灭蚁药物的职业人群肝脏的损伤没有影响；血清7-GT、LDH和CG水平均与血清氯丹和尿砷含量呈 正相关。 [结论]接触灭蚁药物能使职业人群肝功能水平明显损伤。 关键词：职业接触；灭蚁药物；肝功能水平 A Study on Liver Function Damage in Workers Occupational Exposed to Termite Control Drugs ZHU Bao—li，BAN y0 一hong，CHENMin(JiangsuProvince Centerfo Disease ControlandPrevention，Nanjing 2100O9．China) Abstract： [Objective]To explore the level of liver function damage in workers exposed to the termite control drugs． [Methods]7-GT，LDH and CG in serum and other relevant liver function indices together with chlordane in serum and arsenic content in urine of the workers exposed to termite control drugs were investigated．The influences of factors such as the exposed period，smoking，drinking and the content of chlordane in serum or arsenic in urine on the liver function were alSO analyzed． [Results]The levels of 7-GT，LDH and CG were significantly higher in all exposed groups than that in the control(尸0．05)， and correlated with the exposed time．Drinking could enhance the damage to liver function(尸0．05)。but smoking did not．The levels of 7-GT，LDH and CG all correlated with the concentration of chlordane in serum and arsenic in urine．[Conclusion] Long period exposure to the termite control drugs containing chlordane or arsenic compound may lead to damage of liver function． Key Words：occupationally exposure；ter