乙肝母婴阻断168例临床分析.pdfVIP

第22卷 第6期 内蒙古民族大学学报(自然科学版) Vo1．22 No．6 2007年 12月 Journal of Inner Mongolia University for Nationalities Dee．2007 乙肝母婴阻断1 68例临床分析 金艳霞，王 萍，李光晨 (通辽市传染病医院，内蒙古通辽 028000) [摘 要】目的：探讨乙型肝炎表面抗原(I-ms~)阳性母亲分娩新生儿实施母婴阻断的最佳方案．方法：通过总 结通辽市传染病医院和通辽市铁路医院168铡HBsag阳性母亲分娩新生儿实施母婴阻断后的血清HBV标 志物资料．根据不同阻断方案分成三组：重组酵母疫苗组、联合免疫组、官内阻断组．结果：官内阻断组保护率 最高，达到96．0％．HBV官内感染率最低；联合免疫组效果优于重组酵母疫苗组．结论：HBV母婴传播与母亲 I-Ineag或HBV—DNA阳性显著相关，免疫失败的重要原因是官内感染，产前多次注射mIG(高效价免疫球 蛋白)可减少宫内感染． [关键词】乙型肝炎病毒；官内感染；母婴阻断 [中图分类号 n71 [文献标识码】A [文章编号~1671—0185(2007)06—0685—02 Clinical Analysis on the Measures Interrupting Mother‘——to‘——baby Transmission of HBV：1 68 Cases Reports JIN Yan—xia，WANG Ping，LI Guang—chen (TongtiaO City Infectious Diseases Hospital，Tongliao 028000，China) Abstract：0bjective：To find out the best measure to interrupt mother—to—baby transmission of HBV for the pregnant women with positive HBsAg．Methods：Summarizing and analyzing the data of serous markers of HBlv of 168 pregnant women with positive}羽BsAg in Tongliao city infectious diseases and rmlway hospitals．AIl patients were divided into 3 groups according to the interruption measures：via recombinant vaccine，combined immunization and intrauterine interruption．Results： The effective rate of intrauterine interruption amounted to 96．0％ and the newborn showed the lowest intrauterine infection rate．The effect of combined immunization Was better than that of re． eombinant vaccine．Conclusion：There are close correlations between the mother—to—baby trans— mission rate and positive HBsAg and HBV—DNA．It can reduce the incidence of intrauterine in— fection by multiple prenatal injection of HBIG． Key words：HBV：Intraute