神经肽Y、钙基因相关肽和P物质在甲状腺中的分布及其在甲亢状态下的变化.pdfVIP

动物学报 54(5)：830—835，2O08 Acfr上2ro0ff cnSncn Distributi0n 0fNPY，SP，CGRP in ratthyr0id and theirchange underc0nditi0n 0facuteexperimentalhyperthyr0idism LUO Zhen—Gu0，YU Sha0一Wen“，HU Ping，WANG An．Tai，ZHANG Yu ， HUANG Gu C0UegeofLf Sciencs，ShenzhenUniversity，Shenzhen 51806O，Guangd0ng，China Abstract neViousworkhasshownthatpeptide昭icnerefibeI弓0fthethyroidg1andcontainvasoactiveintestina1polypeptide (VIP)，substanceP(SP)andneumpeptideY (NPY)．Theycontaetvesselwa11sandepitheIialce1lsoff0lliclesandregu1atethe acfjvityoftbesⅢo0thmusc1eandepitheliu瑚 Dftbefol】ljc1e．Itisgenefallyaccepted出atthehypotha】amic—pimitary thyr(】idaxis regulatestheactivity0fthyr0idf0llicles．Theacti0nofNPY，CGRPandSP，epecia1lyinhypenhyr0idism，isp0odyunderst00d ． Theacutehyperthymidismratmodelwasinducedbyinjecti0n0fthyr(】xine(T4)．NPY，CGRP，SPweretestedbyRIA．The locationanddistributi0nofNPY，CGRPandSPwerestudiedusingimmun0hist0chemistrv．NPYp0sitiveneⅣe berssurr0unded thesmallb100dvessels，andtheirtem inalscontactedendothelia1cells0fbl0odvesse1s．S0meNPY andSPDositivenerve矗bers werel0calizedinc0nnectivetissuebetween南1licles，andthe打 把nninalscon￡actedf0llicularepjthe1iaIcells．N0CGRP p0sidve nerve矗berswere detected．CGRP p0sitivecellsweredistrihuted within the epih【elium nff0llicles0radjacentt0 f01licles． Radioimmun0assayreVea1edahigher1evel0fNPYandSPinexperimentalratsf0110wingT4印plicati0nascomparedwithc0ntml rats，butthelevel0fCGRPwaslowerthanincontr0ls．Inhyperthvroidism，increasedvas0constricti0ncausedbvincreasingof NPY 0verc0mestheweakenedvas0dj1atione ctsofCGRPdecreasingtodecreasebloodn0wandcontm1s jntoh】oodcjrcu1afjon． Thisbalancemaybeconsideredasoneofhome0stasismechanismunderpmcess0fpathol0gy[Ac把z002og 。sn 54 (5)： 830—835，20o8]．