11药理学（11 pharmacology）.docVIP

11药理学（11 pharmacology） 2011 pharmacy intermediate supervisor of pharmacist exam outline (366) - pharmacology Key points of the unit 1. Introduction 1. The concept of pharmacology, the concept of task and content pharmacology, and the mastery of research contents 2. Preclinical research on the pharmacology of new drugs and proficiency in clinical research 1. Classification and concept of adverse drug reactions of drugs: side effects, toxic reactions, allergic reactions, secondary reactions, aftereffects, and teratogenicity 2. Familiar with the concept, characteristics, type and regulation of receptor (1) receptor (2) receptor theory 3. Overview of pharmacodynamics (1) excitant, antagonist, competitive antagonist, non-competitive antagonist, and drug action mechanism (2) the amount of structure-activity relationship and drug effect relationship and related concepts: the minimum effective volume, minimum amount of poisoning, quantity, quality, efficiency, median effective dose, median lethal dose and treatment index, the index of safety, security line, Polaris 4. Factors influencing the effectiveness of the drug (1) : age, sex, heredity, individual differences, species differences and so on (2) effects of drugs: dosage forms, dosage, administration methods, repeated drug use and drug interactions (3) proficient in tolerance, resistance, dependence and addiction Three, pharmacokinetic (1) of drugs in vivo process of transmembrane transport way, drug absorption, distribution and excretion and its influencing factors, plasma protein binding rate and the enterohepatic circulation, the concept of common P450 enzymes and their inhibitors and inducers, grasp skilled 2. Pharmacokinetic pharmacokinetic relationship between basic concepts and important parameters: medicine - the area under the curve, bioavailability, tmax, drug peak concentration, elimination half-life, apparent volume of distribution and clearance grasp skilled 4. Introduction to the pharmacology of the nervous