糖肾复元汤治疗糖尿病肾病临床探究.docVIP

糖肾复元汤治疗糖尿病肾病临床探究[摘要] 目的:观察糖肾复元汤治疗糖尿病肾病（DN）的疗效。方法：将120例DN患者分为治疗组85例，对照组35例。两组均常规应用洛汀新10 mg/d，根据病情使用胰岛素或格列喹酮（糖适平）、二甲双胍控制血糖。治疗组在此基础上加用糖肾复元汤口服，疗程为8周。观察治疗前后空腹血糖（FPG），餐后2 h血糖（PG），血尿素氮（BUN）、肌酐（Scr），24 h尿蛋白定量（Uprot），尿微量白蛋白排泄率（UAER）的变化。结果：治疗组总有效率显著优于对照组（P＜0.01）；同时能明显减少 Uprot，Scr，BUN，UAER水平，两组比较P＜0.05或P＜0.01。结论：糖肾复元汤治疗DN疗效显著，中西医结合治疗DN优于单用西药治疗。 [关键词] 糖肾复元汤； 糖尿病肾病；尿蛋白；血糖；尿素氮；肌酐 [中图分类号] R255.4 [文献标识码]B [文章编号]1673-7210（2008）09（a）-080-02 Clinical research on the treatment of DN with Tangshen Fuyuan Decoction CHEN Ji-de1,SI Ting-lin1,MENG Qin1,HOU Hui-zhen1,GAO Lian-ying1,WANG Ming-qin1,CHEN Chen2 (1.The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250001，China;2.Class 2, Grade 2006 Clinical Medicine, Shandong University, Jinan 250001,China) [Abstract] Objective:To observe Tangshen Fuyuan decoction’s effect on DN.Methods: Divide 120 patients of DN into 2 groups: 85 in the treatment group; while 35 in the other. Besides the normal treatment to the two groups, such as Benazepril; Insulin or Gliquidone, Meformin to control the blood glucose，Tangshen Fuyuan Decoction was added to the treatment group for 8 weeks. Comparing fasting plasma glucose(FPG), plasma glucose after 2 h of food, blood urea nitrogen(BUN), serum creatinine(Scr), urinary protein test in 24 h(Uprot), and urinary albumin excretion ratio(UAER)before and after treatment of the group.Results: For the treatment group, the total effect was superior and at the same time, Uprot, Scr, BUN, UAER decreased. Comparing the two group P＜0.05 or P＜0.01.Conclusion: Tangshen Fuyuan decoction is particularly effective against DN.Combination of traditional Chinese medicine and Western medicine is better than Western medicine alone on the treatment of DN. [Key words] Tangshen Fuyuan Decoction; DN; Urine protein; Blood glucose; UN; Scr 糖尿病肾病（diabetic nephropathy，DN）是糖尿病（DM）最严重、最常见的微血管并发症之一，也是糖尿病患者主要的死亡原因，延缓或阻止DN的进展，具有重要的临床意义。自2000年10月~2007年8月我们对85例糖尿病肾病患者采用糖肾复元汤治疗，取得良好效果，现报