西酞普兰联合丁螺环酮治疗老年抑郁症临床探究.docVIP

西酞普兰联合丁螺环酮治疗老年抑郁症临床探究【摘要】目的：探讨西酞普兰联合丁螺环酮治疗老年抑郁症的临床疗效和不良反应。方法：将80例符合CCMD-3诊断标准的老年抑郁症患者随机分为观察组和对照组各40例，观察组采用西酞普兰联合丁螺环酮治疗，对照组仅用西酞普兰，疗程8周，采用汉密尔顿抑郁量表（HAMD）、汉密尔顿焦虑量表（HAMA）和副反应量表（TESS）评定疗效和不良反应。结果：治疗后4周末、8周末观察组的HAMD和HAMA平均减分率高于对照组，差异均存在统计学意义(P＜0.05)；两组间的不良反应发生率差异无显著性，均未出现严重不良反应。结论：西酞普兰联合丁螺环酮治疗老年抑郁症安全有效，不良反应少而轻，值得临床推广应用。 【关键词】西酞普兰；丁螺环酮；老年抑郁症；疗效；安全性 Clinical study on the efficacy of citalopram combined with buspirone in treatment of senile depression XIONG Xue-zhi (The Psychiatric Hospital of Ziyang, Ziyang China 641300) 【Abstract】Objective: To explore the clinical efficacy and side effects of citalopram combined with buspirone in the treatment of senile depression. Methods: 80 cases patients confirmed to CCMD-3 standards were randomly divided into the intervention group(40 cases) and control group(40 cases).The intervention group were treated citalopram combined with buspirone, the control group were treated citalopram; After treatment for4, 8 weeks, the therapeutic effects and side effects were evaluated by HAMD, HAMA and TESS. Results: The score of HAMD and HAMA of intervention group was significantly lower than that of control group, there were significant differences(P＜0.05). The differences of the side effects between the two groups were not significant, no serious adverse reactions. Conclusion: Citalopram combined with buspirone is an effective and safe antidepressant in the treatment of the senile depression, fewer and lighter side-effects，and worthy of being recommended for use in clinical practice. 【Key words】citalopram; buspirone; depression; senile depression; efficacy;safety 抑郁症是一种常见的心理障碍，影响了患者的正常生活和学习。我国已经入老龄化时期，老年抑郁症的发病率呈上升趋势，已成为一个公共卫生问题。国内的一些研究提出，老年人随着日常生活能力的下降，社会活动减少以及慢性躯体疾病所致的躯体疼痛和精神压力，导致孤独、寂寞、自卑等抑郁情绪的产生，使其自杀意念强烈，老年人的自杀比例是中青年的3倍[1]。由于老年人躯体、心理和社会关系等各方面的特殊性，因此，临床治疗上相对复杂。2008年1月～2011年1月期间，我们采用西酞普兰联合丁螺环酮治疗老年抑郁症，临床效果满意，现报道如下。 1资料与方法 1.1一般资料80例患者均来自我院门诊或住院部，其中男32例，女48例；年龄60岁～83岁，发病年龄28岁～79岁，病程6个月～15年，13例有家族史。伴随躯体性疾病：心血管疾病者21例、糖尿病者14例、胃肠道疾病