Nampt与糖尿病肾病炎症-纤维化关系的研究进展.pdfVIP

2136 重庆 医学 2015年 5月第44卷第 l5期 Es] ViatteL，Lesbordes--BrionJC，LouDQ，eta1．Deregulation meostasisanderythropoiesis[J]．Gastroenter0logy，2014， ofproteinsinvolvedin ironmetabolism in hepcidin-defi— 146(3)：630-642． eientmi~eU]．Blood，2005，105(12)：4861—4864． [16]HaaseVH．Hypoxicregulationoferythropoiesisandiron [6] RamosE，KautzL，RodriguezR，eta1．Evidencefordis— metabolism[J]．Am JPhysiolRenalPhysiol，2010，299 tinctpathwaysofhepcidinregulationbyacuteandchronic (1)：1—13． ironloadinginmiceEJ]．Hepaotlogy，2011，53(4)：1333— [17]MastrogiannakiM ，MatakP，MathieuJR，eta1．Hepatic 1341． HIF-2 down-regulates hepcidin expression in mice [7] CorradiniE，MeynardD，WuQ，eta1．Serumandliveriron through epo—mediated nicreasein erythropoiesis[J]． differently regulate the bone morphogenetic protein 6 Haematologica，2O12，97(6)：827—834． (BMP6)一SMADsignalingpathwayinmice[J]．Hepatolo— [18]NicolasG，ChauvetC，ViatteL，eta1．Thegeneencoding gY，2011，54(1)：273—284． tlqeironregulatorypeptidehepcidin isregulatd byane— [8] EnnsCA，Ahm(dR，WangJ；eta1．Increasedironloading mia，hypoxia，andinflammation[J]．JClinInvest，2002， inducesBmp6expressioninthenOD：一parenchymalcellsof 110(7)：1O37—1044． *heliverindependentofh*eBMP—signalingpah*way[J]． [19]HintzeKJ，McClungJP．Hepcidin：acriticalregulatorof PqosOEJe，2O13，8(4)：7811—7819． ironmetabolism duringhypoxia[J]．AdvHematol，2011 [9] FinbergKE，WhittleseyRL，FlemingMD，eta1．Doww (4)：510304． regulationofBmp／Smad signaling by Tmprss6 is re— [2O]VolkerH．Regulationoferythropoiesisbyhypoxia-induc— quiredformaintenanceofsystemicironhomeostasis[J]． iblefactors[J