肥胖对PCOS血清白介素-6表达影响.docVIP

肥胖对PCOS血清白介素-6表达影响[摘要] 目的:研究IL-6在肥胖与PCOS发病机制中的作用。方法:分别选择20例PCOS肥胖患者、非肥胖PCOS患者、肥胖对照患者及非肥胖对照患者,记录临床特征,检测血清生殖激素及血清IL-6。结果:IL-6浓度在不肥胖且非PCOS、肥胖但非PCOS、PCOS非肥胖、PCOS且肥胖女性的血清中依次显著升高。结论:肥胖和PCOS都与血清高水平IL-6相关,IL-6既能够参与肥胖的病理生理过程,也能够参与PCOS的病理生理过程。肥胖加重PCOS血清白介素-6的表达。 [关键词] 多囊卵巢综合征;白介素-6;肥胖 [中图分类号] R392.2[文献标识码]A [文章编号]1673-7210(2010)02(c)-031-02 Effect of obesity on the expression of serum IL-6 in PCOS XIA Yudong (Wuxi College of Technology Health, Wuxi 214171, China) [Abstract] Objective: To investigate the role of IL-6 in the pathophysiology of obesity and polycystic ovary syndrome (PCOS). Methods: 20 cases of obese PCOS women, non-obese PCOS women, obese control women and non-obese control women were respectively selected. The clinical characteristics were recorded, the reproductive hormone and serum IL-6 were measured. Results: The level of IL-6 in the serum was increased in order among the subjects of non-obesity non-PCOS, obesity but non-PCOS, PCOS but non-obesity and PCOS and obesity. Conclusion: Both obesity and PCOS are related to the serum IL-6 level. IL-6 plays a certain role in the pathophysiology of obesity and PCOS. Obesity increases the expression of serum IL-6 in PCOS. [Key words] Polycystic ovary syndrome; Interleukin 6; Obesity 多囊卵巢综合征(polycystic ovary syndrome,PCOS)以高雄激素、不排卵和多囊卵巢为根本特征,是育期女性常见的生殖内分泌疾病,起病于青春早期,具有典型的异质性,主要表现为月经紊乱、闭经、多毛、肥胖、双侧卵巢囊性增大,伴有高雄激素血症及胰岛素抵抗[1]。白介素-6(interleukin 6,IL-6)是一种多功能的糖蛋白细胞因子,IL-6分子量为19～28 kD,多种细胞都可以产生IL-6,IL-6具有促进损伤后的组织修复与再生的功能[2]。在生殖系统中,IL-6参与排卵及排卵后卵巢修复,一方面,IL-6抑制雌二醇、孕酮和睾酮的表达;另一方面,排卵后的雌激素和孕酮升高后又能抑制IL-6的产生[3]。因此,IL-6在生殖系统中发挥重要作用。研究显示,PCOS患者体内IL-6水平较高[4],提示IL-6在PCOS发病过程中起一定的作用。 肥胖也是PCOS的一个显著特征,超过50%的PCOS患者有肥胖特征[5]。肥胖一般发生于PCOS发病前或发病早期,提示肥胖可能在PCOS的发病机制中起重要作用[6]。目前认为,慢性炎症可能是代谢综合征和2型糖尿病的触发因子,而肥胖作为其中的重要部分,亦认为是一种慢性炎症性疾病[7]。肥胖者血液循环中的IL-6水平升高,而且与BMI水平相关[8]。IL-6是一种细胞因子,具有广泛的免疫调节作用,IL-6既可以由免疫活性细胞产生,也可以由脂肪细胞产生。Pedersen等[9]证实肥胖患者的脂肪组织能够分泌大量的IL-6;Hrnciar等[10]亦研究发现,在一组肥胖、胰岛素抵抗伴高瘦素血症的患者中,28%的患者IL-6水平升高。 既然IL-6与肥胖和PCOS的发病都