静滴环磷酰胺出现剧烈头痛二例（There were two cases of severe headache with intravenous drip of cyclophosphamide）.docVIP

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静滴环磷酰胺出现剧烈头痛二例（There were two cases of severe headache with intravenous drip of cyclophosphamide）.doc

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静滴环磷酰胺出现剧烈头痛二例（There were two cases of severe headache with intravenous drip of cyclophosphamide）

静滴环磷酰胺出现剧烈头痛二例（There were two cases of severe headache with intravenous drip of cyclophosphamide） There were two cases of severe headache with intravenous drip of cyclophosphamide 2011-05-08 Tang Fulin, Wei Yanqiu, Zhang Yaping, Wu Qingjun Example 1: female, 12 years old. Facial erythema appeared in July 1997, aggravated after sun exposure, accompanied by erythema at heel and heel. The erythrocyte sedimentation rate (ESR) was 35 mm/1 H. ANA, 1, 640, anti ds-DNA 1: 40, anti SSA 1: 64, RF 1: 32. AcL negative. CH50 40 U/ml (50~100 U/ml), C3 500 mg/L (850~1930 mg/L). Systemic lupus erythematosus, sle. Take prednisone 40 mg/d, chloroquine 0.25 g/d. After 1 months, the condition was stable and prednisone was gradually reduced. 4 months later, taking chloroquine and erythema to azathioprine and disabled, 0.1 g/d, 4 months. Because of repeated facial erythema not faded, with both hands to stop vasculitis, azathioprine, cyclophosphamide treatment, intravenous infusion of G for the first time in 0.6 after about 3 h headache, fever 38 degrees, nausea, vomiting and consciousness disorder, oral analgesics no relief, the headache, suspected of lupus encephalopathy, by methylprednisolone the impact of 0.8 g 3 D, lumbar puncture: intracranial pressure of 180 mm H2O, cerebrospinal fluid protein negative, white blood cells of 5 / L. CSF sugar 2.8 mmol/L, protein 0.4 mmol/L, chloride 128 mmol/L. The bacteria were negative for culture and no TB bacilli were found. No Cryptococcus was detected by ink staining. No abnormal head CT. Review ANA 1: 320, anti ds-DNA negative, normal range of CH50 and C3, normal blood and urine, lupus encephalopathy and infection were not supported. The trial of cyclophosphamide 0.2 g intravenous injection did not appear headache, two weeks after the test will be added to 0.4 g intravenous cyclophosphamide, again with symptoms of headache. The relief of headache was reduced to 0.2 g after intravenous injection. To the cumulative dosage of 2.8 g, cyclophospha