adverse reactions of commonly used anti-hypertensive drugs and countermeasures（常用的降压药物的不良反应和对策）.docVIP

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2017-09-05 发布于浙江
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adverse reactions of commonly used anti-hypertensive drugs and countermeasures（常用的降压药物的不良反应和对策）.doc

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adverse reactions of commonly used anti-hypertensive drugs and countermeasures（常用的降压药物的不良反应和对策）

Adverse reactions of commonly used anti-hypertensive drugs and countermeasures Author: Xu Hong the weighted approximation Zhang Fang Zhang Jie Zhang Wenbo Wang Xinxia Zhang Yanmin [Words] antihypertensive drug adverse reactions countermeasures Current clinical commonly used anti-hypertensive drugs, including thiazide diuretics, angiotensin-converting enzyme (ACE inhibitors, angiotensin receptor blockers (ARBs, beta-blockers, calcium channel blockers and @ blockers. these drugs can produce some adverse reactions. understanding of these adverse reactions, and to take appropriate measures to ensure the safe use of antihypertensive drugs. A thiazide diuretic Thiazide diuretics for antihypertensive treatment has more than 40 years of history, a series of randomized, double-blind clinical trial affirmed its efficacy and safety. Recently American Joint Committee JNC 7 (hypertension prevention, detection, evaluation and treatment The the 7th report reaffirms thiazides as first-line antihypertensive drug status [1]. larger doses of thiazide diuretics (such as hydrochlorothiazide thiazidegt; 50 mg / d often of metabolic adverse effects, the current treatment guidelines recommend The dosage for hydrochlorothiazide 12.5 ~ 25 mg / d, and the adverse reactions were rare. possible adverse reaction of thiazide diuretics as follows. 1.1 hypokalemia 25 mg / d of hydrochlorothiazide allows lower serum potassium of 0.3 to 0.4 mmol / L, if used in combination with ACE inhibitors or ARBs, serum potassium increased slightly due to these two drugs can be, no need potassium. elderly, diabetic patients taking digoxin or basic low potassium levels may be considered plus Paul potassium-sparing diuretics such as triamterene piperidine. 1.2 hyperlipidemia short-term use of thiazide diuretics may total cholesterol (TC), low-density lipoprotein cholesterol (LDL C increased by 7%, and high-density lipoprotein cholesterol (HDL C was not affected long-term application