a note on qtl detecting for censored traits报告审查性状的qtl检测.pdfVIP

Genet. Sel. Evol. 38 (2006) 221–229 221 c INRA, EDP Sciences, 2006 DOI: 10.1051/gse:2005037 Note A note on QTL detecting for censored traits Yixin Fang∗ Department of Statistics, Columbia University, New York, NY 10027, USA (Received 9 August 2005; accepted 6 October 2005 ) Abstract – Most existing statistical methods for mapping quantitative trait loci (QTL) assume that the phenotype follows a normal distribution and that it is fully observed. However, some phenotypes have skewed distributions and may be censored. This note proposes a simple and ef- ficient approach to QTL detecting for censored traits with the Cox PH model without estimating the baseline hazard function which is “nuisance”. QTL detecting / censored trait / interval mapping 1. INTRODUCTION The standard approach for mapping the quantitative trait loci (QTL) con- tributing to variation in a quantitative trait makes use of the assumption that the phenotype is normally distributed and fully observed [7,8,11,18]. In recent years, many authors have proposed nonparametric or semiparametric meth- ods to solve the problem of model misspecification caused by the assump- tion of normality [6, 10, 19]. In addition, assumptions of standard approach are likely to be false when the phenotype pertains to the survival time or fail- ure time and the failure time is often subject