hplc method determination of injection oxiracetam oxiracetam by content（高效液相色谱法测定注射oxiracetam oxiracetam内容）.docVIP

HPLC method Determination of Injection Oxiracetam Oxiracetam by content Papers to write network: [words] Oxiracetam Abstract: Objective to establish the injection Oxiracetam of Oxiracetam content determination method method of high performance liquid chromatography, silica gel as a filler aminosilane key mobile phase of acetonitrile in water (volume ratio of 80:20, detection at 210 nm. Results Oxiracetam mass concentration in the range of 0.025 ~ 0.20 mg / mL and peak area showed a good linear relationship (r = 10000, precision and repeatability of test results RSD were 0.10% and 0.30%, The average recovery rate was 100.85%, RSD = 0.79%. CONCLUSION The method is simple, sensitive, accurate, reproducible, and the establishment of quantitative methods can be used to control the quality of the injection. Keywords: Oxiracetam Injection, assay, high performance liquid chromatography Abstract: Objective To establish a quick and efficient highperformance liquid chromatographic assay for the determination of oxiracetam in oxiracetam injection. Method Chromatography was performed on a column (250/4.6 NUCLEOSIL 1005 NH2) using acetonitrilewater (80:20) as the mobile phase under the detection wavelength of 210 nm. Result The linear range was 0.025 ~ 0.20 mg / ml (r = 1.0000. The average recovery was 100.85% and RSD 0.79%. Conclusion The method is convenient, sensitive and accurate for the quality control of oxiracetam injection. Keywords:: oxiracetam; oxiracetam injection; content determination; HPLC Injection Oxiracetam main ingredient for Oxiracetam Oxiracetam (chemical name: 4-hydroxy-2-oxo-pyrrolidine amide is an intelligent promotion of drugs, can improve thinking and memory function and academic performance, prevention and treatment of the elderly significant effect of dementia [1]. the determination of Oxiracetam content, foreign literature column switching method [2] and pre-column derivatization method [3], the domestic Kjeldahl method paper usi