hplc method for the determination of rosiglitazone extended release tablets（罗格列酮的高效液相色谱方法测定扩展发布平板电脑）.docVIP

HPLC method for the determination of rosiglitazone extended release tablets Papers network: [Keywords] rosiglitazone hydrochloride Abstract: Objective To establish the method of determination of rosiglitazone content of the sustained-release tablets. Methods using high performance liquid chromatography, silica gel as stationary phase Octadecylsilanized, 0.05 mol / L sodium acetate (adjusted with glacial acetic acid pH 6.0 methanol (25:75) as the mobile phase, detection wavelength 247 nm, and Determination of rosiglitazone hydrochloride sustained-release tablets content. rosiglitazone hydrochloride in the concentration range of 10.15 ~ 6090 μg · mL good linearity relationship (r = 0.9998), and the recovery was 100.3% (RSD = 0.65% Conclusion The method rosiglitazone sustained release tablets, the results are accurate, feasible. Keywords: rosiglitazone hydrochloride sustained-release tablets, high performance liquid chromatography Abstract: Objective To establish a method for the determination of rosiglitazone in sustainedrelease tablets. Method HPLC was performed on a C18 column (250 mm × 4.6 mm, 5 μm) using 0.05 mol / L sodium acetate (pH 6.0) methanol (25:75 ) as the mobile phase at a flow rate of 1.0 mL · min-1. The detection wavelength was at 247 nm. Results The standard curve was linear in the range of 10.15-60.90 μg · mL-1 with correlation coefficient 0.9998. The average recovery was 100.3% with RSD 0.65%. Conclusion The method is convenient, accurate and reliable for the quality control of rosiglitazone sustainedrelease tablets. Keywords:: rosiglitazone; sustainedrelease; HPLC Rosiglitazone (rosiglitazone oral treatment of type 2 diabetes, thiazolidinediones, TZDs can enhance the body’s sensitivity to insulin, to regulate the transcription of insulin-responsive genes control the generation, transfer and utilization of blood glucose, to rectify sugar and lipid metabolic disorders, lower fasting and postprandial blood glucose, improve glu