影响脑梗死患者预后相关因素分析及血尿酸检测 意义.docVIP

影响脑梗死患者预后相关因素分析及血尿酸检测 意义 　 作者：田海军 马燕妮 李朝武 【关键词】 脑梗死；相关因素；血尿酸 【摘 要】 目的 探讨影响急性脑梗死患者近期预后的相关因素及血尿酸检测的意义。方法 分析86例急性脑梗死患者临床资料及血尿酸含量。结果 未愈组与康复组比较，有高血压病史者比例和Cr、UA、ApoA1水平较高(P＜0.05），而有吸烟、心肌梗死史、卒中史者比例及GLU、TC、TG、LDL、HDL、ApoB的水平无统计学意义（P＞0.05）。Logistic回归分析筛选出三个主要影响因素：高血压病史、UA水平和ApoA1水平。血尿酸水平与脑梗死患者的预后相关，血尿酸水平高者，病情重，预后差（P＜0.001）。结论 脑梗死预后与高血压病史、血尿酸等危险因素有关，测定血尿酸含量有助于判断病情及评估近期预后。 　【关键词】 脑梗死；相关因素；血尿酸 　【Abstract】 Objective To investigate the prognostic related factor in acute cerebral infarction patients and the significance of serum uric acid detection. Methods To analyse the clinical data and the content of serum uric acid in 86 patients with acute cerebral infarction. Results Compared to restoration group, the proportions of patients with hypertension record and the level of Cr, UA and ApoA1 were higher in nonrestoration group (Plt;0.05).The proportions of patients with smoking,myocardial infarction, apoplexy and the level of GLU, TC, TG, LDL, HDL, ApoB were not statistically significant between two groups (P＞0.05). Three main impact factors were screened by Logistic regression analysis,which are hypertension record, the content of UA and the level of ApoA1.The content of serum uric acid was correlated with the prognosis of cerebral infarction patients. The patients with higher serum uric acid concentration had bad prognosis（P＜0.001）. Conclusion The prognosis of cerebral infarction was correlated with some risk factors, such as hypertension record and serum uric acid level. The determination of serum uric acid content was conduced to the estimate of pathologic condition and the evaluation of prognosis. 　【Key words】 Cerebral infarction;Related factor; Serum uric acid 脑梗死是一种严重威胁中老年人的常见病。由于脑血液供应的改变，使脑组织缺血缺氧，脑细胞变性坏死，局灶性神经功能缺失，甚至意识改变，严重者危及患者生命。尽管目前有较为先进及完善的治疗手段，但仍有较大一部分幸存者生活不能完全自理，极大地影响了人类的生存质量。本文对86例急性脑梗死患者影响近期预后的相关因素进行分析，并探讨血尿酸检测在脑梗死防治中的意义。 1 资料与方法 1.1 研究对象 选择我院2000年1月～2006年7月神经内科住院的急性脑梗死患者86例，均为发病后24 h内入院，符合第4届全国脑血管病会议制订的诊断标准，并经头颅CT扫描或MRI证实。脑梗死同时合并脑出血等其他脑血管病变者不在入选中。排除了痛风、肾脏疾病(血肌酐