白芍饮片的质量现状与质量控制方法研究进展.docVIP

白芍饮片的质量现状与质量控制方法研究进展 严倩茹 邬伟魁 梅州市食品药品监督检验所 X 关注成功！ 加关注后您将方便地在 我的关注中得到本文献的被引频次变化的通知！ 新浪微博 腾讯微博 人人网 开心网 豆瓣网 网易微博 摘????要： 白芍是我国著名的传统中药,应用历史悠久,而且在很多成方制剂中都有应用。近年来,随着食品药品质量监管的加强,白芍饮片的质量问题日益凸显,如不同产地药材质量不一、硫磺熏制导致饮片质量下降,需要不断提高切实可行的质量控制方法,除了传统的色谱法外,需要扩大一测多评、指纹图谱、快速鉴别等新方法的应用。对白芍饮片的质量现状与质量控制方法进行探讨,以期进一步完善白芍的质量标准,为保证临床用药安全性、有效性和质量控制的科学性提供依据。 关键词： 白芍; 质量控制; 中药饮片; 一测多评; 作者简介：严倩茹,硕士,从事药品质量研究工作。Tel:(0753)2319612E-mail:499476976@ 收稿日期：2014-11-19 Advances in study on quality status and quality control of Paeoniae Alba Radix YAN Qian-ru WU Wei-kui Meizhou Institute for Food and Drug Control; Abstract： Paeoniae Alba Radix is one of famous Chinese materia medica in our country with a long history of applification, which is used in many drug preparation. In recent years, with the strengthening of food and drug supervision, quality problem has become increasingly prominent in Paeoniae Alba Radix, e.g. Paeoniae Alba Radix,from different habitats has the different quality; Sulfur smoked treatment results the decline of the decoction piece quality. In addition to the conventional chromatographic quality control methods of Paeoniae Alba Radix, there are some new methods, such as multi-components quantitation by one marker, chromatographic fingerprints, and rapid identification. It is necessary for improving the quality status of Paeoniae Alba Radix and discussing the research progress in quality control, so as to ensure the scientific clinical drug safety, effectiveness, and quality control, and further improve the quality standard of it. Keyword： Paeoniae Alba Radix; quality control; decoction pieces; multi-components quantitation by one marker; Received： 2014-11-19 白芍是我国著名中药,为毛茛科植物芍药Paeonia lactiflora Pall.的干燥根,其药用历史悠久, 《神农本草经》列为中品,有“主邪气腹痛,除血痹, 破坚积,寒热疝瘕,止痛,利小便,益气”的记载。 白芍有养血敛阴、柔肝止痛、平抑肝阳的功效,其主要成分为芍药苷、芍药苷内酯等,具有抗炎、解痉、镇痛等药理作用[1]。白芍饮片广泛应用于中成药里,如三九胃泰颗粒、十全大补丸、乌鸡白凤丸等。2013年,笔者对川渝两地市售白芍饮片质量进行调研,发现28批样品中仅1批芍药苷含量符合药典规定[2];在日常监督检验工作中,发现白芍饮片合格率低,质量现状堪忧。白芍饮片是中医临床处方直接入药和中成药生产直接投料使用的,有必要对其质量现