75例儿童肥胖遗传风险评估与儿童肥胖的关系.docVIP

精品论文 参考文献 75例儿童肥胖遗传风险评估与儿童肥胖的关系 陈桂霞1 许榕仙2 黄妙惠2 阮莉莉1 李健3（通讯作者）（1厦门市妇幼保健院儿童保健科 361003）（2福建医科大学公共卫生学院 350000）（3厦门市妇幼保健院生殖健康科 361003） 【摘要】目的 探讨4个肥胖基因位点多态性与儿童肥胖的关联性。方法 通过儿童系统保健健康体检筛选体重正常、超重、轻度肥胖、中度肥胖和重度肥胖自愿接受检测儿童各15人；对所选研究对象选择问卷方式获取相关信息；取研究对象口腔粘膜上皮细胞，进行儿童肥胖遗传风险检测；采用SPSS 11.5软件对数据进行统计分析。结果 肥胖组和非肥胖组的出生BMI、父亲BMI、母亲BMI、基因分析结论、喂养方式、喂养时间的差异有统计学意义（Plt;0.05）。而性别、年龄两组间的差异无统计学意义（Pgt;0.05）。epsilon;2epsilon;3epsilon;4(APOE)的基因型分布有统计学差异（X2=9.5238，Plt;0.025）；Hind III(LPL)基因型分布差异有显著性（X2=25.2024，Plt;0.005）；G132A(LEP)基因型分布无显著性差异（X2=3.5714，Pgt;0.05）；Pro12Ala(PPARG)基因型分布有统计学差异（X2=24.2581，Plt;0.005）。结论 APOE epsilon;2epsilon;3epsilon;4、LPL Hind III、 PPARG Pro12Ala 等3个肥胖基因位点多态性对儿童肥胖有影响。因此该项检测对于预测儿童肥胖以及及时采取防范措施有重要意义。 【关键词】儿童肥胖 肥胖遗传风险基因检测 相关因素 【中图分类号】R179【文献标识码】A【文章编号】2095-1752（2012）35-0113-02 The relationship between 75 obesity genetic risk tests and children obesity 【Abstract】Objective: To investigate the relationship between the four obesity gene sites polymorphism and childhood obesity. Method: After well-baby check, 75 children with various body mass were chosen to collect the oral samples, oral mucosal epithelium cells, detect genetic loci. The data was statistically analyzed by the software SPSS 11.5. Results: The overweight group and obesity group：New born BMI , father BMI, genetic analysis conclusion，mother BMI, feeding way, breastfeeding time were different and statistically significant (P lt; 0.05). but gender, age difference between the two groups was statistically significant (P gt; 0.05).epsilon; 2 epsilon; 3 epsilon; 4 (APOE) genotype distribution statistically significant (X2 = 9.5238, P lt; 0.025); Hind III (LPL) genotype distribution difference of the (X2 = 25.2024, P lt;0.005); G132A (LEP) genotype distribution has no significant difference (X2 = 3.5714, P gt; 0.05); Pro12Ala (PPARG) genotype distribution statistically significant (X2 = 24.2581, P lt; 0.005).Conclusion: The 3 obesity gene loci polymorphism of childhood obesity: APOE epsilon; 2