冠状动脉内支架置入术后再狭窄与高尿酸血症的关系.docVIP

精品论文 参考文献 冠状动脉内支架置入术后再狭窄与高尿酸血症的关系 胡艳敏 李凌 　　（郑州大学第一附属医院心血管内科 河南 郑州 450052） 　　【摘要】 目的:分析冠状动脉内支架置入术后再狭窄与高尿酸血症的关系。方法:2012年1月至2013年12月于郑州大学第一附属医院心内科行冠状动脉支架置入术，并于术后1年行冠状动脉造影复查的患者946例，以支架置入段内径狭窄ge;50％为再狭窄为标准，分为对照组(823例)和支架内再狭窄组（123例），回顾性分析两组患者的血清尿酸水平、支架情况及其他临床生化指标的差异。结果:再狭窄组的血清UA水平为(412.08plusmn;70.18)mu;mol/L，明显高于对照组(328.18plusmn;72.89）mu;mol/L，且差异有统计学意义(Plt;0.01)。多因素Logistic逐步回归分析显示，吸烟、糖尿病、支架直径lt;3.5mm、支架长度gt;30mm是冠状动脉支架置入术后再狭窄重要的危险因素，高尿酸血症是支架内再狭窄的另一危险因素(OR=1.653)。结论:冠状动脉内支架置入后再狭窄与高尿酸血症明显相关。 　　【关键词】 冠状动脉支架置入术；高尿酸血症；支架内再狭窄 　　【中图分类号】R541.4 【文献标识码】A 【文章编号】2095-1752（2016）11-0148-02 　　The relationship between intracoronary in-stent restenosis and hyperuricemia disease Hu Yanmin,Li Ling,Department of Cardiology ,the First Affiliated Hospital of Zhengzhou University ,Zhengzhou 450052,China 　　【Abstract】Objective To analyze the relationship betweenintracoronary in-stent restenosis and hyperuricemia disease .Methods Selected 946 patients, who had an operation of coronary artery stent implantation between January in 2012 and December in 2013 in the department of cardiology of theFirst Affiliated Hospital of Zhengzhou University , and reviewd coronary angiography after 1 year. As the standard of in-stent restenosis was luminal diameter narrowing of intracoronary stent by 50% or greater, the cases were divided into the control group (823 cases) and in-stent restenosis group (123 cases).Two groups of cases were retrospectively analyzed serum uric acid level, stents and other clinical biochemical index differences. Results The serum uric acid level of in-stent restenosis group was (412.08plusmn;70.18)mu;mol/L,which was significantly higher than the control group, whose level was (328.18plusmn;72.89) mu;mol/L, and the difference was statistically significant (Plt;0.01). Multivariate logistic regression analysis revealed that smoking, diabetes, stent diameterlt;3.5mm, stent lengthgt;30mm were the important risk factors of in-stent restenos