替米沙坦联合丹参酮ⅡA治疗早期糖尿病肾病临床疗效观察.docVIP

精品论文 参考文献 替米沙坦联合丹参酮ⅡA治疗早期糖尿病肾病临床疗效观察 梁峰翎 刘 虹（通讯作者） 　　湖南省马王堆医院老年综合科 410016 　　摘要：目的：观察替米沙坦联合丹参酮ⅡA治疗早期糖尿病肾病的临床疗效。 　　方法：选取符合1999年WHO 糖尿病诊断标准及DN 早期诊断标准的80例早期糖尿病肾病患者，随机分为对照组和治疗组，每组40例。两组均严格控制血糖和血压在正常范围，对照组单纯使用替米沙坦，治疗组在此基础上给予丹参酮ⅡA，检测治疗12周后患者尿微量白蛋白排泄率（UAER），尿微量白蛋白（MA），肾功能：尿素氮（BUN）、血肌酐（sCr），空腹血糖（FBG）。 　　结果：治疗后，两组患者UAER、MA、BUN、SCr、FPG均有明显下降，差异均具有统计学意义（P＜0.05）；且治疗组总有效率高于对照组。用药过程中，个别患者出现滴注部位不适，减慢滴速后症状得到缓解。 　　结论：替米沙坦联合丹参酮ⅡA 治疗早期糖尿病肾病的疗效显著，可有效降低尿白蛋白排泄率，减少24 h 尿蛋白，改善肾功能，且不良反应少，值得临床推广。 　　关键词：丹参酮ⅡA；替米沙坦；早期糖尿病肾病 　　Methods 80 patients diagnosed early diabetic nephropathy who were in accordance with WHO diagnosis standard in 1999 and DN early diagnosis standard were selected and divided into a study group of 40 patients confirmed application Telmisartan Tanshinone Ⅱ A therapy treatment，the control group of 40 petients confimed application treatment.Total treatment for 12weeks.The two groups were strictly controlled blood glucose and blood pressure in the normal range.the clinical efficacy rate was observed after treatment for 12 weeks.And the urinary albumin excretion rate（UAER）、urinary Albumin/Renal function：urea nitrogen（BUN）、serum creatinine（sCr）、fasting blood glucose（FBG）were observed after treatment for 12 weeks. 　　Results After 12 weeks of treatment，the UAER，MA，SCr，BUN，FPG of the study group and the control group decreased than before treatment，and the differences were statistically significant（P lt; 0.05）；The total effective rate of study group were higher than that of control group，and the differences were statistically significant（P lt; 0.05）.During the process of the treatment，individual patients showed infusion site discomfort，intravenous infusion after the symptoms have been alleviated. 　　Conclusion：Efficacy of Telmisartan combined with Tanshinone Ⅱ A in the treatment of patients with early diabetic nephropathy is significant.They can effectively reduce the urinary albumin excretion rate and the 24 h urinary protein，improve renal function，and less adverse reaction