病毒性角膜炎单纯滴用更昔洛韦与联合口服用药的临床疗效比较.docVIP

精品论文 参考文献 病毒性角膜炎单纯滴用更昔洛韦与联合口服用药的临床疗效比较 （陕西省延安市人民医院眼科 陕西 延安 716000） 【摘 要】目的：比较病毒性角膜炎单纯滴用更昔洛韦与联合口服用药的临床疗效。方法：本研究选取2012年9月至2014年8月80例病毒性角膜炎患者为对象，将其随机分组。对照组患者局部滴用更昔洛韦滴眼液治疗，实验组患者在此基础上联用口服更昔洛韦片治疗。对比分析两组患者治疗效果和不良反应。结果：采用卡方检验分析进行数据统计，实验组总有效率明显高于对照组，不良反应发生率明显高于对照组，差异有统计学意义（P＜0.05）。结论：局部滴用更昔洛韦滴眼液联合口服用药，可提高对病毒性角膜炎的治疗效果，但同时可引起全身不良反应，在今后的临床工作中应酌情使用。 【关键词】病毒性角膜炎；更昔洛韦；滴眼；口服用药；临床疗效 【中图分类号】R772.21 【文献标识码】A 【文章编号】1004-6194（2015）02-0074-02 The clinical curative effect of ganciclovir combined with drops of oral medication of viral keratitis compare Department of Ophthalmology Yanan Peoples Hospital of Shaanxi province Liu Xia Xie Jing zip code: 716000 【Abstract】Objective To compare the viral keratitis simply drop with the clinical curative effect of ganciclovir combined with oral medication. Methods this study selected in 2012 September to 2014 August, 80 cases of viral keratitis patients as the object, it will be randomly grouping. Patients in the control group of topical use of Ganciclovir Eye Drops treatment, patients in the experimental group based treatment with oralGanciclovir Tablets treatment. Comparative analysis of two groups of patients the treatment effect and adverse reaction. The analysis of statistical data by chi square test, the experimental group was better than that in control group, the incidence of adverse reaction was significantly higher than the control group, the difference was statistically significant (P lt; 0.05). Topical ganciclovir eye drops combined with oral administration of conclusion, we can increase the viral keratitis treatment effect, butalso can cause systemic adverse reactions, as appropriate, should be used in clinical work in the future. 【Keywords】viral keratitis; ganciclovir; eye drops; oral drugs; clinical effect 单纯疱疹病毒引起的角膜感染根据角膜病变累及的部位、病理特点可分为四种类型，包括上皮型角膜炎、内皮型角膜炎、基质性角膜炎、神经营养性角膜病变等。上皮型病毒性角膜炎较常见，病毒在上皮细胞内复制、增殖，破坏上皮细胞功能，临床多采用抗病毒药物局部治疗[1]。本研究分析了单纯滴用更昔洛韦与联合口服用药两种方法治疗病毒性角膜炎的临床疗效，现将结果报告如下。 1 资料和方法 1.1一般资料