肺结核合并慢乙肝患者抗结核治疗中联合抗病毒药物的临床评价.docVIP

精品论文 参考文献 肺结核合并慢乙肝患者抗结核治疗中联合抗病毒药物的临床评价 （1.上海市奉贤区古华医院感染科 上海 201400；2.上海市奉贤区古华医院检验科 上海 201400） 【摘 要】目的：观察肺结核合并慢性乙型病毒性肝炎( 乙肝) 患者, 在结核治疗中联合应用恩替卡韦对肝功能和结核治疗依从性的影响。方法：55例服用抗结核药物的慢性乙肝患者, 随机分为2组。27例予抗结核+ 抗病毒治疗+ 护肝为治疗组 ; 28例予抗结核+ 护肝为治疗组，评价治疗前后患者肝功能、HBVDNA变化及结核治疗依从性。结果：对照组肝功能异常率高于治疗组，两者差异显著( P＜0. 05) ; 对照组停药率高于治疗组，结核治疗依从性差，两者差异显著( P＜0. 05), 对照组H BVDNA水平明显较治疗组升高(P lt; 0.05)。结论：抗病毒治疗能明显减轻乙型肝炎合并肺结核的患者抗结核治疗引起的肝功能损害，减少抗结核治疗的停药率,使结核治疗的依从性提高。 【关键词】抗病毒；肺结核；乙型病毒性肝炎 【中图分类号】R521 【文献标识码】A 【文章编号】1004-6194（2015）02-0319-02 Clinical evaluation of pulmonary tuberculosis combined with antiviral drug of anti tuberculosis treatment in chronic hepatitis B patients 【Abstract】Objective：To observe the effect of combined application of patients with pulmonary tuberculosis complicated with chronic hepatitis B in the treatment of pulmonary tuberculosis patients in the entecavir on hepatic function and tuberculosis treatment compliance. Method：55 patients with chronic hepatitis B patients with anti tuberculosis drugs, randomly divided into 2 groups.27 patients were treated with antiviral treatment with anti tuberculosis and treatment for liver protection as treatment group;28 were treated with anti tuberculosis and liver as treatment group,Compliance of evaluation before and after treatment changes in patients with liver function and HBV-DNA and anti tuberculosis treatment. Result：The control group was higher than that of the treatment group with abnormal liver function,The difference is significant(Plt;0.05);The control group was higher than that of the treatment group discontinued,Adherence to anti tuberculosis treatment difference The difference is significant(Plt;0.05),The control group the level of HBV-DNA was significantly higher than the treatment group The result is increased(Plt;0.05). Conclusion：Liver function damage of antiviral therapy can significantly reduce the hepatitis Bpatients with pulmonary tuberculosis caused by anti tuberculosis tre