普拉洛芬滴眼液对恢复老年性白内障超声乳化术后泪膜稳定性的临床研究.docVIP

普拉洛芬滴眼液对恢复老年性白内障超 声乳化术后泪膜稳定性的临床研究 金慧瑜撤W 武汉市中心医院耳鼻喉科华中科技大学同济医学院 职工医院 B的观察单纯玻璃酸钠治疗与玻璃酸钠联合普拉洛芬治疗对老年性白内障术后 泪膜稳定性恢复的变化。方法回顾性临床病例-对照研究。将2010年3月2012 年3月在本科诊治的老年性0内障超声乳化术的患者60例（96眼）分为对照组 （玻璃酸钠组48眼）和治疗组（玻璃酸钠联合普拉洛芬组48眼）。观察术前，术 后1周、2周、1个月术眼干眼的主观症状，泪膜破裂时间（BUT）,基础泪液分 泌试验（S I t）及角膜荧光素染色（FL）等泪膜指标的临床检查。结果与术前 比较，治疗组干眼主观症状、BUT、Sit及FL值在2周后恢复到术前水平，而 对照组的术后指标在1个月后才恢复到术前水平。2组术前泪膜指标比较差异均 无统计学意义（P〉0.05）。结论在治疗老年性白内障超声乳化术后的干眼中， 联合使用普拉洛芬滴眼液可以有效缓解干眼主观症状，并能快速、安全地恢复泪 膜的稳定性。 关键词： 白内障超声乳化;泪膜;普拉洛芬;玻璃酸钠;干眼; 罗浩（Email: 1372345143@） 2016—11 -07 Clinical study of sodium pranoprofen on recovery of tear film stability after phacoemulsification in senile cataract JIN Hui-yu LIN Ling LUO Hao Department of Ophthalmology， Liyuan Hospital， Tongji Medical College, Science and Technology University of Huazhong; Abstract： Objective To study the effect of the combined treatment with hyaluronatc (HA) and pranoprofen for senile patients after phacoemulsification in dry eye ( recovery of tear film stability) . Methods Sixty patients who had undergone phacoemulsification from March 2010 to March 2012 were randomly divided into the control group ( 48 eyes with HA) and the treatment group ( 48 eyes with HA and pranoprofen) . Subjective symptoms, tears film break-up time ( BUT)，Schirmer I test (Sit) and corneal fluorescein staining ( FL) were measured preoperatively and 1 week， 2 weeks and 1 month postoperatively. Results Subjective symptoms, BUT, Sit and FL in the treatment group returned to preoperative value at 2 weeks after phacoemulsification. But the above measurements in the control group returned to preoperative value at 1 month after phacoemulsification. There were no statistically significant differences in the ( P 0. 05) preoperative indexes of dry eye between the two groups. Conclusions The combined treatment with pranoprofen and HA at early stage after phacoemulsification could be more effective to relieve the dry eye symptoms for senile patients. Keyword： Phacoemulsification; Tear film; Pranoprofen; Hyalur