小呼吸道功能和痰嗜酸性粒细胞在儿童咳嗽变异性支气管哮喘缓解期测定的意义.pdfVIP

·1224· ·呼吸系统疾病· 小呼吸道功能和痰嗜酸性粒细胞在儿童咳嗽变异性 支气管哮喘缓解期测定的意义 陆彬彬，陆超，沈燕 【摘要】 目的探讨小呼吸道功能及痰嗜酸性粒细胞(EOS)监测在咳嗽变异性支气管哮喘(哮喘)缓解 期患儿中的意义。方法对52例咳嗽变异性哮喘缓解期患儿进行肺功能检查并采集诱导痰，记录小呼吸道功 进行痰EOS分类计数。另选择16例健康儿童为健康对照组。结果52例咳嗽变异性哮喘缓解期患儿存在一 定程度的小呼吸道功能障碍，表现为MEF50显著低于健康对照组(P0．01)，而痰EOS计数显著高于健康对 照组(P0．01)。哮喘复发i3次／年的患儿小呼吸道功能明显低于复发3次／年的患儿。MEFS0低于80％ 预计值、痰EOS计数≥4％的患儿哮喘复发次数多。结论在咳嗽变异性哮喘缓解期同时监测小呼吸道功能 及痰EOS计数对监测病情有重要作用。 【关键词】 小呼吸道功能；痰嗜酸性粒细胞；咳嗽变异性支气管哮喘 Valueofsmall functionand number inchildmnwith variantasth- airway sputumeosinophilsmomto—ng cough maatremissionLU Province period Bin—bin，LUChao，sHENYan．DepartmentofPediatrics，JiangsuHospital，the First Medical AffiliatedHospitalofNanjing University，Nanjing210000，China author：S翻r．7、『Yah，Emaif：fubinbin_006@163．con Corresponding To thevalueofsmall functionand numbermoni- 【Abstract】Objectiveinvestigate airway sputumeosinophils in with variantasthmaatremission function andindueed ehildren toting cough period．MethotisPulmonaryparameters from52childrenwith variantasthmaatremissionwerecollected．Theindicatorsofsmall sputumsamples cough period includedforced flowafter and recur- function 25％，50％and75％(MEl725，MEF50MEF75)were airway expiratory takenascontrol numberwasmeasured．Sixteenchildrenwere Small ded．Sputumeosinophils healthy group．ResulIs functionwas indifierent inthechildrenwith variantasthmaatremission airway impaired degrees COUgh period．The MEF50ofthe variantasthma weremuchlowerthanthatofcontrol with cough patients