COX2与Ecad在子宫内膜腺癌组织表达及其意义.docVIP

COX2与Ecad在子宫内膜腺癌组织表达及其意义 【摘要】目的探讨环氧合酶2（COX2）与上皮型钙黏素（Ecad）在子宫内膜腺癌组织表达及其临床意义。方法应用免疫组化EnviSion法检测20例正常子宫内膜和70例子宫内膜腺癌中COX2、Ecad表达情况。结果子宫内膜腺癌组织中COX2表达阳性率则明显高于正常子宫内膜组织（P=0.000 0），而Ecad表达阳性率则明显低于正常子宫内膜组织（χ2=18.79,P0.001）；COX2表达阳性率与病人年龄、病理分级及手术病理分期均无关（Hc=1.050、5.566、5.358，P0.05），而与子宫肌层浸润深度及淋巴结转移有关（uc=3.015、5.237，P0.01）；Ecad 表达阳性率与病理分级、手术病理分期、子宫肌层浸润深度及淋巴结转移均有关（χ2=4.389，P0.05、0.01）；子宫内膜腺癌组织COX2的表达与Ecad呈负相关（r=-0.264，P0.05）。结论在子宫内膜腺癌的发生发展中COX2和Ecad可能起重要作用；COX2表达与子宫内膜腺癌侵袭和转移关系密切，Ecad可能是COX2表达调控的重要因子之一。 【关键词】 环氧合酶2 上皮型钙黏素 子宫内膜肿瘤 免疫组织化学 EXPRESSION OF COX2 AND Ecad AND ITS SIGNIFICANCE IN ENDOMETRIAL ADENOCARCINOMANIU ZHAOSHAN， JI XIANGRUI (Laboratory of Micromorphology, Qingdao University Medical College, Qingdao 266071, China) ［ABSTRACT］ObjectiveTo study the expression of Cyclooxygenase2 (COX2) and Ecadherin (Ecad) in endometrial adenocarcinoma and its clinical significance. MethodsThe expression of COX2 and Ecad in normal endometrium (n=20) and endometrial adenocarcinoma (n=70) was measured by EnviSion immunohistochemistry. ResultsThe positive expression rate of COX2 in the endometrial adenocarcinoma was significantly higher than that in the normal endometrium (62.86% vs 0), while that of the Ecad in the adenocarcinoma was significantly lower than that in the normal endometrium (45.71% vs 100.00%, chi;2=18.79, P0.001). The expression of COX2 was not correlated with the patientrsquo;s age，pathological grade and clinical stage （Hc=1.050，5.566，5.358;P0.05 ）, but correlated with the myometrial invasion and lymph node metastasis （uc=3.015,5.237；P0.01）. Inverse correlation was observed between the expressions of COX2 and Ecad in the malignancy （r=-0.264，P0.05）. ConclusionCOX2 and Ecad may play an important role in the pathogenesis of endometrial adenocarcinoma；COX2 expression is closely related to the infiltration and metastasis of this disease，and Ecad may be one of major regulators in the COX2 expression. ［KEY WORDS］cyclooxygenase2; Ecadh