介孔涂层包覆镁合金材料的制备 降解和生物性能的分析-preparation, degradation and biological properties analysis of mesoporous coating coated magnesium alloy materials.docxVIP

ABSTRACTDue to the good mechanical properties, in vitro and in vivo biocompatibility, and degradability, magnesium (Mg) and its alloys have been regarded as the candidate for the application as the biodegradable bone repair materials recently. However, the clinic use of Mg alloys is mainly restricted owing to the too fast initial corrosion rate in body fluids. Surface modification is an efficient way to protect Mg alloys and control their corrosion behavior. Compared with the conventional coatings materials, mesoporous materials have the narrow distribution of pore size, large specific surface area and enhanced surface wettability, which favor for the promotion of biological properties of the substrates. It could be hypothesized that Mg alloys coated with mesoporous coatings would exhibit suitable properties for bone repair.In this paper, mesoporous hydroxyapatite (HA) and mesoporous HA/45S5 glass-ceramic composite coatings were respectively prepared on the glass or Mg alloy substates using a sol-gel dip-coating method, and the process was optimized to prepare the uniform and crack-free coatings. Mesoporous HA with different pore structure was prepared using CTAB or F127 as the templates by varing pH value and template concentration. Therein, the mesoporous HA prepared using 0.192 g/mL of F127 template achieved the mesopores sized in 3.17 nm, and its pore volume andspecific surface area were 0.38 cc/g and 211.7 m2/g. The uniform and crack-freemesoporous coating with the thickness in ~1.0 μm was prepared on Mg alloy substrate.Using simulated body fluids (SBF) as the corrosion medium, the influence of the porous structure and composition of the coatings on the corrosion behavior of Mg alloy was studied, and the mechanism of the mesoporous coatings to prevent Mg alloy from rapid corrosion was explored. The immersion tests showed that the presence of mesoporous structure would decline the elastic modulus of the coating and the effect of residual stress on it