翻白草降糖降脂作用及机理初探实验分析-experimental analysis on hypoglycemic and lipid-lowering effects and mechanism of potentilla discolor.docxVIP

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翻白草降糖降脂作用及机理初探实验分析-experimental analysis on hypoglycemic and lipid-lowering effects and mechanism of potentilla discolor.docx

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翻白草降糖降脂作用及机理初探实验分析-experimental analysis on hypoglycemic and lipid-lowering effects and mechanism of potentilla discolor

摘要predictthat95%ethanolwastheanti-diabeticmaterialbaseinvitro.Thisextractioneliminaterateof·OHandinhibitrateofnitrationreached26.9%and58.6%,respectively.So,PotentilladiscolorBungecananti-freeradicals.Theanimalexperimentshowsthat,thegluoftreatedratshavebeenobviouslydecreasedwhichcomparedwiththemodelgroupP0.05invivo(Tab.4-4).TheTotalcholesterolandLowdensitylipoproteinwerealsoobviouslydecreasedwhichcomparedwiththemodelgroupP0.05(Tab.4-5Tab.4-8).Insummary,presentationadescriptiontheircurrenttrendsasfollows:Hypoglycemiceffect(Fig.4-4):MetforminHClthe95%exteactsofPotentilladiscolorBungeTangniaole;Totalcholesterol(Fig.4-5):the95%exteactsofPotentilladiscolorBungeMetforminHClTangniaole;Lowdensitylipoprotein(Fig.4-8):MetforminHCl～the95%exteactsofPotentilladiscolorBungeTangniaole;Triglyceride(Fig.4-6):MetforminHClTangniaolethe95%exteactionsofPotentilladiscolorBunge;Highdensitylipoprotein(Fig.4-7):Tangniaolethe95%exteactsofPotentilladiscolorBunge～MetforminHCl.ThebiochemicalindicesrevealthatPotentilladiscolorBungehavetheeffectofhypoglycemicandlipid-lowering.Comparetotwopositivecontroldrugwhichareknown,PotentilladiscolorissuperiortoTangniaole,butinferiortoMetforminHCl.Forexperimenttimetooshort,inducethatgroupshavenoobviousdifferecesinpathologicaltesting.Atthesametime,therearenoobviousabnormalinPotentilladiscolor,Bungtreatedgroup,whichdiscriptedthatitsSideeffectisn’tsoheavyanditissafe.ThisprojectresultsshowtheefficiencyofourstudiesmethodsbydifferentextractionsofthePotentilladiscolorBungeplantpharmacodynamicsscreening.Besides,itsantihyperglycaemicandantihyperlipidaeticactivityarebelongtocertaincompositionsinPotentilladiscolorBunge.ThispharmacologystudyofferedexperimentbasisandtheoreticalguidanceforPotentilladiscolorBungephytochemistryandsearchingnewhypoglycemiamedicine.Besides,thenitritionmodelwasusedinDMscreeningofChineseherbmedicineinvitrothatisaIV摘要innovationsinthispaper.KEYWORDS:PotentilladiscolorBunge;diabetesmellitus;pharmacodynamics;invitro;invivoDissertationType:BasicResear