局限期小细胞肺癌放疗疗效及其预后因素研究-study on radiotherapy efficacy and prognostic factors of limited stage small cell lung cancer.docxVIP
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局限期小细胞肺癌放疗疗效及其预后因素研究-study on radiotherapy efficacy and prognostic factors of limited stage small cell lung cancer
IV
IV
Abstract
3.COX proportional hazards model for multivariate analysis imply that whether concurrent chemoradiotherapy, KPS score, NSE level at first diagnosis, the efficacy of first-line therapy are independent prognostic factor in limited-stage small lung cancer.
Conclusion:
radiotherapy dose DT ﹤ 50Gy, Radiation therapy later, not concurrent chemoradiotherapy, not undergo PCI, Low KPS score, anemia at first diagnosis, NSE increased at first diagnosis, the poor of First-line treatment curative effect, is the poor
prognostic factors of limited-stage small cell lung cancer. whether concurrent chemoradiotherapy, KPS score,NSE level at first diagnosis, the First- line treatment curative effect is the independent prognostic factor.
Keywords: Small cell lung cancer; Limited-stage; Radiation therapy;Prognosis Analysis
目录
目录
PAGE
PAGE VI
目 录
第 1 章 引言 1
第 2 章 对象与方法 4
2.1 研究对象 4
2.1.1 纳入标准 4
2.1.2 排除标准为 4
2.2 研究内容 5
2.2.1 一般资料 5
2.2.2 分组标准 5
2.3 治疗方法 6
2.3.1 放射治疗 6
2.3.2 化学治疗 7
2.4 疗效评价 8
2.4.1 近期疗效评价 8
2.4.2 生存率 8
2.5 随访 8
2.6 统计学分析方法 9
第 3 章 结果 10
3.1 患者一般资料、生存时间和生存率 10
3.2 全组患者临床病理及治疗方法对生存的影响单因素分析 10
3.2.1 性别对 LD-SCLS 预后的影响 12
3.2.2 年龄对 LD-SCLS 预后的影响 13
3.2.3 KPS 对 LD-SCLS 预后的影响 14
3.2.4 贫血对 LD-SCLS 预后的影响 15
3.2.5 NSE 对 LD-SCLS 预后的影响 16
3.2.6 肿瘤位置对 LD-SCLS 预后的影响 17
3.2.7 放疗方式对 LD-SCLS 预后的影响 18
3.2.8 放疗剂量对 LD-SCLS 预后的影响 19
3.2.9 放疗介入时间对 LD-SCLS 预后的影响 20
3.2.10 是否同步放化疗对 LD-SCLS 预后的影响 21
3.2.11 一线治疗后疗效对 LD-SCLS 预后的影响 22
3.2.12 PCI 对 LD-SCLS 预后的影响 23
3.3 LD-SCLS 预后的多因素分析 24
第 4 章 讨论 25
4.1 性别对 LD-SCLS 预后的影响 25
4.2 年龄对 LD-SCLS 预后的影响 26
4.3 KPS 对 LD-SCLS 预后的影响 26
4.4 贫血对 LD-SCLS 预后的影响 27
4.5 NSE 对 LD-SCLS 预后的影响 27
4.6 肿瘤位置对 LD-SCLS 预后的影响 27
4.7 放疗方式对 LD-SCLS 预后的影响 28
4.8 放疗剂量对 LD-SCLS 预后的影响 29
4.9 放疗介入时间对 LD-SCLS 预后的影响 30
4.10 是否同步放化疗对 LD-SCLS 预后的影响 30
4.11 一线治疗后疗效对 LD-SCLS 预后的影响 31
4.12 PCI 对 LD-SCLS 预后的影响 31
第 5 章 结论与展望 32
5.1 结论 32
5.2 展望 32
致 谢 33
参考文献 34
综 述 38
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