探讨血清同型半胱氨酸、超敏C反应蛋白联合检测临床应用价值.docVIP

探讨血清同型半胱氨酸、超敏C反应蛋白联合检测临床应用价值 　　doi：10.3969/j.issn.1007-614x.2014.3.62 　　摘 要 目的：探讨血清同型半胱氨酸（Hcy）、超敏C反应蛋白（hs-CRP）联合检测的临床应用价值。方法：收治冠心病患者165例，分为3组，急性心肌梗死（AMI）组49例，不稳定型心绞痛（UAP）组54例，稳定型心绞痛（SAP）组62例。急性脑梗死（ACI）组60例，2型糖尿病肾病患者组63例，健康对照组50例。超敏C-反应蛋白采用乳胶增强免疫比浊定量法，同型半胱氨酸采用循环酶法检测。结果：冠心病3组（165例）、急性脑梗死组（60例）、2型糖尿病肾病组（63例）的血清同型半胱氨酸、超敏C反应蛋白检测水平较健康对照组（50例）有明显升高（P0.05）。AMI组、ACI组、2型糖尿病肾病患者，同型半胱氨酸、超敏C反应蛋白含量与病情严重程度呈正相关。结论：血清同型半胱氨酸、超敏C反应蛋白检测可作为急性心肌梗死（AMI）和急性脑梗死（ACI）的危险预测因子，其水平变化与ACI、AMI的病情程度密切相关，Hcy、hs-CRP联合检测更有助于ACI、AMI患者的诊断和为预后提供更好的判断指标，有助于判断2型糖尿病肾病患者病情变化。 　　关键词 同型半胱氨酸 超敏C-反应蛋白 冠心病 急性脑梗死 糖尿病肾病 　　Clinical application value of the combined detection of serum homocysteine and high-sensitivity C reactive protein 　　Zhang Qiwei，Li Shunkang 　　Clinical laboratory of the first peoples Hospital of Neijiang City， Sichuan Province，641000 　　Abstract Objective：To explore the clinical application value of the combined detection of serum homocysteine and hypersensitive C-reactive protein.Methods：We selected 165 cases of patients with coronary heart disease.165 cases were divided into three groups，including acute myocardial infarction（AMI）group of 49 patients，unstable angina pectoris（UAP） group of 54 cases，stable angina pectoris（SAP）group of 62 cases.Acute cerebral infarction（ACI）group had 60 patients，type 2 diabetes nephropathy group of 63 cases，50 cases in the control group.Hypersensitive C-reactive protein was measured by particle-enhanced turbidimetric immunoassay and homocysteine was measured by enzymatic cycling method.Results：In three coronary heart disease group（165 cases），acute cerebral infarction group（60 cases）and type 2 diabetic nephropathy group（63 cases），the serum homocysteine and hypersensitive C-reactive protein levels were higher than the healthy control group（50 cases）.The difference was statistically significant（P0.05）.In the AMI group，ACI group and type 2 diabetic nephropathy group，the levels of homocysteine and hypersensitive C-reactive protein were positive correlation with t