他汀类药物联合丹红注射液治疗动脉粥样硬化临床效果.docVIP

他汀类药物联合丹红注射液治疗动脉粥样硬化临床效果 　　【摘 要】目的：探讨他汀类药物联合丹红注射液在动脉粥样硬化治疗中的临床疗效，提高治疗效果。方法：将我院心内科收治的经颈动脉彩超确诊的120例颈动脉粥样硬化患者作为观察对象，随机分为观察组和对照组各60例。对照组口服阿司匹林、阿托伐他汀钙等，观察组则在此基础上联合丹红注射液，比较两组患者治疗后的临床疗效。结果：观察组IMT治疗前为（1.31±0.21）mm，治疗后（0.82±0.32）mm;对照组治疗前为（1.31±0.24）mm，治疗后为（1.08±0.16）mm，两组治疗前IMT差异无统计学意义（Pgt;0.05），治疗后治疗组IMT低于对照组（Plt;0.05）。观察组治疗后TG、TC、LDL-C、ox-LDL、hs-CRP差异有统计学意义（Plt;0.05）。结论：他汀类药物联合丹红注射液治疗动脉粥样硬化具有较好的临床效果，值得借鉴。 　　【关键词】他汀类药物; 动脉粥样硬化; 丹红注射液 　　Clinical effect of the combined treatment of Dan-hong injection and atorvastatin for atherosclerosis 　　[Abstract] Objective To study the efficacy of the combined treatment of Dan-hong injection and atorvastatin for atherosclerosis and aimed to improve the clinical effect. Methods 120 patients collected from our hospital were divided into two groups randomly， namely control group and observation group and each group were 60 patients. The control group was given general western medicine treatment and the observation group was combine Dan-hong injection on the basis of control group. Compare the clinical effect of two group after 8 weeks. Results The observation group of IMT level was （1.31±0.21）mm and the level fall into （0.82±0.32）mm after treatment， while the control group was （1.31±0.24）mm before treatment and （1.08±0.16）mm after treatment. The two groups of IMT before treatment has no statistically significant （Pgt;0.05） and has significant difference after treatment（Plt;0.05）. The hs-CRP， IMT， TG， TC，LDL-C， HDL-C level of the two group had significant difference （Plt;0.05）. Conclusion The combined treatment of Dan-hong injection and atorvastatin had positive clinical effect and worth learning. 　　[Keywords] Statins drugs Atherosclerosis Dan-hong injection 　　有资料认为，动脉粥样硬化（AS）是因内膜损伤而导致动脉发生的炎症-纤维增生性反应性疾病[1]，但具体发病机制尚未完全明确，近年来关于动脉粥样硬化的发病机制，许多学者倾向于”内皮损伤反应学说”，因此如何通过防止动脉内膜中层厚度增厚成为组织动脉粥样硬化斑块形成的关键[2]。本文进一步探讨他汀类药物联合丹红注射液在动脉粥样硬化中的治疗效果，现报道如下。 　　1 资料与方法 　　1.1 一般资料 将我院心内科2012年1月-2013年12月收治的动脉粥样硬化患者作为观察对象，随机分为对照组和观察组各60例。对照组男36例，女24例;年龄42～83岁，