脑清通颗粒对高血压模型大鼠et、angⅱ、cgrp影响的实验研究-experimental study on the effect of naoqingtong granule on et, ang ⅱ and cgrp in hypertensive rats.docxVIP
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脑清通颗粒对高血压模型大鼠et、angⅱ、cgrp影响的实验研究-experimental study on the effect of naoqingtong granule on et, ang ⅱ and cgrp in hypertensive rats
week,the2ndweek,the3thweek,wemeasuredthefollowingphysiologicalindexs:endothelin(ET),angiotensinⅡ(AngⅡ),calcitonin-gene-relatedpeptide(CGRP),bloodfat,andbloodrheology.Result:EachdosegroupofNaoTaiTonggranulehadthesignificanteffectofpreventingthebloodpressurefromrising,especiallyinthe3thweek,ascomparedwithitselfbeforemedicinetreatmentandwiththemodlegroup(p0.05),whichwasmorepronouncedintheNaoTaiTonggranulelargedosegroupandmediumdosegroup;inaddition,thecontentofET、AngⅡ,bloodfat,andbloodrheologywassignificantlyreducedintheNaoTaiTonggranulelargedosegroupandmediumdosegroupascomparedwiththemodelgroup(p0.05orp0.01).Conclusion:TheeffectofNaoTaiTonggranuleontreatinghypertensionmightarisefromitsroleinlesseningthecontentofET、AngⅡ、CGRP,andbloodfat,henceimprovingthefunctionofvascularwallanddegradingthelevelofbloodpressure.Keywords:Thehypertension;NaoTaiTonggranule;hepaticheatandphlegmstasis;ET;AngⅡ;CGRPAuther:lixiangTutor:LiJun目录引言.............................................................1一理论部分.......................................................31.中医学对高血压病的认识...........................................31.1理论渊源........................................................31.2病因病机........................................................41.3辨证要点及治疗原则..............................................61.4肝热、痰、瘀与高血压病.........................................62.现代医学对高血压病的认识.........................................72.1病因与发病机制..................................................72.2诊断标准及水平分级标准.........................................102.3临床常用的降压药物.............................................10二实验部分......................................................131实验目的........................................................132实验材料........................................................132.1实验动物.......................................................132.2药品及试剂.....................................................132.3仪器及设备.....................................................132.4实验动物分组.............................
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