Snail介导EMT在上皮性卵巢癌组织中作用.docVIP

Snail介导EMT在上皮性卵巢癌组织中作用 　　[摘要] 目的 检测Snail、E-cadherin及Vimentin在上皮性卵巢癌组织中的表达，探讨Snail介导的上皮间质转化（EMT）在卵巢癌发生、发展及转移中的作用。 方法 采用免疫组化法分别检测Snail、E-cadherin、Vimentin在48例卵巢浆液性腺癌、卵巢交界性浆液性肿瘤及卵巢浆液性腺瘤中的表达，探讨EMT相关因子表达强度的相关性及与临床病理特征之间的关系。 结果 （1）Snail、Vimentin在卵巢浆液性腺癌中的表达率为（68.75%/66.67%），高于卵巢交界性浆液性腺瘤的（41.67%/37.50%）及卵巢浆液性腺瘤的（25.00%/18.75%），结果均具有显著的统计学差异（P0.05）。（2）Snail、E-cadherin及Vimentin的表达高低与FIGO分期、分化级别、有无淋巴结转移及腹膜种植有关。（3）在卵巢浆液性腺癌中，Snail与Vimentin的表达呈正相关（r=0.477，P0.05）。结论 在上皮性卵巢癌组织中，Snail、Vimentin表达上调，E-cadherin表达下调，提示Snail介导的EMT可能与卵巢癌的发生、发展及浸润转移有关。 　　[关键词] Snail；E-cadherin；Vimentin；上皮性卵巢癌；上皮间质转化 　　[中图分类号] R737.31 [文献标识码] A [文章编号] 2095-0616（2014）07-09-06 　　Effects of Snail mediated EMT in epithelial ovarian carcinoma 　　TANG Qing1 HOU Jianqing2 　　1.Medical College of Qingdao University，Qingdao 266000，China；2.Department of Gynecology，Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University，Yantai 264000，China 　　[Abstract] Objective To Study the effect on Snail mediated epithelial mesenchymal transition （EMT） in ovarian cancer occurrence， development and metastasis. Methods Immunohistochemical staining was detected Snail， E-cadherin，in 48 cases of ovarian serous adenocarcinoma，ovarian serous borderline tumors and ovarian serous adenomas Vimentin，investigate the correlation between the expression of EMT -related factors and the strength and relationship between clinicopathological features. Results （1）The expression of Snail，Vimentin in ovarian serous adenocarcinoma was 68.75% and 66.67%，higher than in borderline serous ovarian tumors （41.67% and 37.50） and in ovarian serous adenomas（ 25.00% and 18.75%），with significant difference（P0.05）.（2）The expression level of Snail and FIGO， E-cadherin and Vimentin staging，differentiation level，there was no lymph node metastasis and peritoneal implants.（3）in ovarian serous adenocarcinoma， the expression of Snail positively correlated with Vimentin （r=0.477，P 　　[Key words] Snail；E-cadherin；Vimentin；Epithelial ovarian can