PCOS患者不同促排卵方案宫腔人工授精结局.docVIP

PCOS患者不同促排卵方案宫腔人工授精结局 　　【摘要】 目的：比较不同促排卵方法的多囊卵巢综合征患者的宫腔人工授精结局，以找出最佳的促排卵方法指导临床治疗。方法：161例周期接受宫腔人工授精的PCOS患者，根据患者个人意愿分为克罗米芬组（A组），克罗米芬组+HMG组（B组），HMG组（C组），比较三组的临床资料和促排卵结局。结果：三组患者平均年龄、不孕年限、成熟卵泡数、临床妊娠率、OHSS发生率、多胎率比较差异均无统计学意义（P0.05），但B组临床妊娠率最高；A组hCG日内膜明显薄于其他两组，且流产率高，差异有统计学意义（P0.05），B组、C组两组比较，B组Gn天数少，Gn用量小，差异有统计学意义（P0.05）。结论：三个促排卵方案均适用于PCOS患者，克罗米芬+HMG方案可获得相对高的临床妊娠率，流产率低，且使用Gn天数少，Gn用量小，可作为首选促排方案。 　　【关键词】 多囊卵巢综合征； 宫腔人工授精； 促排卵 　　中图分类号 R588.6 文献标识码 A 文章编号 1674-6805（2014）15-0006-03 　　The Intrauterine Insemination Outcome of PCOS Patients by Different Stimulate Ovulation/XU Hao-li，ZHANG Li-na，KONG Shao-shan，et al.//Chinese and Foreign Medical Research，2014，12（15）：5-8 　　【Abstract】 Objective：To compare the intrauterine insemination（IUI） outcome of PCOS patients by different stimulate ovulation，to find out the best stimulate ovulation.Method：161 cases of PCOS who cycle underwent in intrauterine insemination.They were divided into clomiphene（CC） group（group A），CC+HMG group（group B），HMG group（group C） according to personal willingness.The clinical data and the outcome of the three groups were compared.Result：There were no significant difference among the three groups in patients’ average age，infertility，the number of mature follicle，the clinical pregnancy rate and the incidence of OHSS，multiplets rate（P0.05），but the highest clinical pregnancy rate was group B，the hCG day endometriums was thinner and the abortion rate was higher in group A than those of the other two groups（P0.05）.Comparing group C and group B，the less Gn days and the small Gn dosage in group B than that of group C，the differences were statistically significant（P0.05）.Conclusion：All three stimulate ovulation scheme are applicable to patients with PCOS，The CC+ HMG group can be used as first choice for high clinical pregnancy rate and low abortion rate，the less Gn days and the small Gn dosage. 　　【Key words】 Polycystic ovary syndrome； Intrauterine insemination； Stimulate ovulation 　　First-author’s address：Zhuhai Mate