IFN―γ含量测定在结核性胸膜炎患者临床诊断中效果分析.docVIP

IFN―γ含量测定在结核性胸膜炎患者临床诊断中效果分析 　　【摘要】 目的：探究IFN-γ含量?y定在结核性胸膜炎患者临床诊断中的应用效果。方法：选取本院2016年1月-2017年12月呼吸内科收治的50例结核性胸膜炎患者为研究组及非结核性胸膜炎50例患者为对照组，同期选择院内体检的健康者50例为健康组，均采用酶联免疫吸附试验对研究组及对照组患者进行胸腔积液，并对3组患者外周血血清中IFN-γ含量进行测定并比较。结果：经测定后，研究组患者胸腔积液中IFN-γ浓度为（1 460.65±100.76）pg/mL显著高于对照组（250.89±30.53）pg/mL，差异有统计学意义（P0.05），研究组患者血清中IFN-γ浓度为（75.32±13.81）pg/mL显著高于对照组（42.45±10.33）pg/mL及健康组（43.67±12.08）pg/mL，差异有统计学意义（P0.05）；研究组患者ROC曲线分析结果显示，胸腔积液中IFN-γ浓度300 pg/mL为临界值，IFN-γ浓度的测定对结核性胸腔积液诊断的特异度为93%，诊断灵敏度为98%。50例结核性胸膜炎患者治疗后的总有效率为90.0%，2例出现胸膜肥厚粘连，其余患者均无严重并发症及不良反应发生。结论：对胸膜炎患者进行酶联免疫吸附试验检测胸腔积液及外周血血清中IFN-γ含量可显著提升结核性胸膜炎的诊断效能，值得临床推广采用。 　　【关键词】 IFN-γ； 结核性胸膜炎； 临床诊断 　　Effect Analysis of IFN-γContent Determination in Clinical Diagnosis of Tuberculous Pleurisy/PENG Chang.//Medical Innovation of China，2018，15（07）：104-107 　　【Abstract】 Objective：To explore the clinical application of IFN-γ content determination in the clinical diagnosis of tuberculous pleurisy.Method：50 cases of tuberculous pleurisy patients in our hospital from January 2016 December to 2017 Department of respiratory medicine were selected as research group and 50 patients of non tuberculous pleurisy in the control group，selected the same period in the hospital physical examination of 50 healthy cases as healthy group，they were given enzyme-linked immunosorbent assay to study group and control group of patients with chest effusion， and 3 groups of patients with IFN-γ content of peripheral blood serum were measured and compared.Result：After the test，the study group with pleural effusion in IFN-γ concentration was （1 460.65±100.76）pg/mL significantly higher than the control group （250.89±30.53）pg/mL，the difference was statistically significant （P 　　【Key words】 IFN-γ； Tuberculous pleurisy； Clinical diagnosis 　　First-author’s address：People’s Hospital of Gaoming District，Foshan528500，China 　　doi：10.3969/j.issn.1674-4985.2018.07.029 　　结核性胸膜炎是临床常见的一种呼吸内科疾病，主要因患者受结核杆菌及其自溶产物侵害胸膜从而致使胸膜炎症的产生所致，患者临床症状表现为发热、出汗、食欲不振及盗汗，同时伴有胸腔积液，引起呼吸困难，严重威胁患者生命安全[1]。相关调查