IgA肾病患儿促纤溶治疗对肾脏保护功能回顾性分析.docVIP

IgA肾病患儿促纤溶治疗对肾脏保护功能回顾性分析 　　[摘要] 目的 探究促纤溶在IgA肾病患儿的治疗中对肾脏功能临床影响。 方法 选取2014年7月―2015年8月间在该院进行治疗的IgA肾病患儿84例，按随机投掷法进行分组，研究组42例行一般治疗，对照组42例在一般治疗中结合纤溶酶，对比两组间生化指标及不良反应。结果 治疗后研究组ALB、TP、CH、TG、Scr、尿蛋白定量、Ccr相比于对照组均有所好转（P0.05）。治疗后研究组转氨酶升高11.905%、皮肤瘀斑21.429%、牙龈出血16.667%、呕吐26.190%、粘膜出血23.810%相比于对照组23.810%、45.238%、35.714%、47.619%、52.381%均有所降低（P0.05）。结论 对IgA肾病患儿实施促纤溶治疗后，明显改善了肾脏的水平，降低了不良反应，提高预后。 　　[关键词] 肾脏功能；IgA肾病；促纤溶治疗 　　[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742（2016）03（c）-0055-03 　　Retrospective Analysis of Effect of Fibrinolysis-Promoting Treatment for Children with IgA Nephropathy on Renal Protection Function 　　YANG Li， CAO Guang-hai， LIU Cui-hua， LI Hong-jiang， TIAN Ming， WU Li-juan 　　Department of Nephrology and Rheumatism， Zhengzhou Childrens Hospital， Zhengzhou， Henan Province， 450000 China 　　[Abstract] Objective To discuss the clinical effect of fibrinolysis-promoting treatment for children with IgA nephropathy on renal function. Methods 84 cases of children with IgA nephropathy treated in our hospital from July 2014 to August 2015 were randomly divided into two groups with 42 cases in each， the research group were given general treatment， the control group were treated with plasmin on this basis， the biochemical indicators and adverse reactions of the two groups were compared. Results After treatment， the ALB， TP， CH， TG， Scr， urine protein quantitation and Ccr in the research group were improved compared with those in the control group（P0.05）， after treatment， the transaminase elevation， skin ecchymosis， gingival bleeding， vomiting and mucosal bleeding in the research group were decreased compared with those in the control group（11.905%， 21.429%， 16.667%， 26.190%， 23.810% vs 23.810%， 45.238%， 35.714%， 47.619%， 52.381%）（P0.05）. Conclusion Fibrinolysis-promoting treatment for children with IgA nephropathy can obviously improve the renal level， decrease the adverse reaction and improve the prognosis. 　　[Key words] Renal function； IgA nephropathy； Fibrinolysis-promoting tr