TCTHPV―DNA联合阴道镜检查在宫颈病变诊断中应用价值.docVIP

TCTHPV―DNA联合阴道镜检查在宫颈病变诊断中应用价值 　　【摘要】目的：探讨TCT、HPV-DNA联合阴道镜检查在宫颈病变诊断中的应用价值。方法：选取2013年3月至2015年5月在我院同时行TCT、HPV-DNA及阴道镜检查的650例患者作为研究对象，对其中1项或以上检查异常者行病理活检，以病理学分级为标准分析诊断结果。结果：650例受检者中TCT阳性102例，其中ASCUS 80例，LSIL 15例，HSIL 6例，SCC 1例，HBV-DNA阳性40例，阴道镜阳性58例；TCT阳性病理活检结果为CINⅠ 16例，CINⅡ 10例，CINⅢ 4例，浸润癌2例；TCT、HPV-DNA联合阴道镜检查诊断CINⅠ、Ⅱ、Ⅲ准确率明显高于TCT联合HPV-DNA，差异有统计学意义（P0.05）。结论：TCT、HPV-DNA联合阴道镜检查是一种高效、快速的宫颈癌筛查方式，可为宫颈癌的临床诊断提供依据，在临床上具有重要应用价值。 　　【关键词】 液基细胞学检查； 人乳头瘤病毒；阴道镜；宫颈病变 　　Application value of TCT， HPV-DNA combined with vaginal examination in diagnosis of cervical lesionsQIN Yingming， ZHANG Xiuju， WANG Wei， YUE Li. Department of Obstetrics and Gynecology， Bazhong Traditional Chinese Medicine Hospital， Bazhong 636000， Sichuan， China 　　【Abstract】Objectives： To investigate the application value of TCT， HPV-DNA combined with vaginal examination in diagnosis of cervical lesions. Methods： 650 patients received TCT， HPV-DNA and vaginal examination in our hospital from March 2013 to May 2015 were selected. Pathological biopsy was performed on patients with 1 or more abnormal diagnosis results. Diagnosis results were analyzed with the pathological grade. Results： There were 102 patients with positive TCT result in 650 cases， including 80 cases with ASCU， 15 cases with LSIL， 6 cases with HSIL and 1 cases with SCC； 40 patients with positive HPV-DNA test result were found； 58 patients were found with positive colposcopic result. Among the patients with positive TCT result， there were 16 patients with CIN I， 10 patients with CIN II， 4 cases with CIN III and 2 patients with invasive carcinoma； The accuracy of TCT， HPV-DNA combined with vaginal examination in diagnosis of CIN I， II and III was significantly higher than that in TCT and HPV-DNA， with statistically significant difference （P0.05）. Conclusion： The TCT， HPV-DNA combined with vaginal examination is an effective and fast screening method for cervical cancer， which can provide the basis for clinical diagnosis of cervical cancer and has impor