亚临床甲状腺功能减低合并脂肪肝代谢性危险因素分析.docVIP

亚临床甲状腺功能减低合并脂肪肝的代谢性危险因素分析 　　[摘要] 目的 探讨亚临床甲状腺功能减低合并脂肪肝的检出率及代谢性危险因素分析。 方法 回顾性调查2013年份健康体检资料，采用病例对照研究方法对亚甲减与非亚甲减的代谢性危险因素进行比较；采用单因素t检验分析亚临床甲减组合并脂肪肝与不合并脂肪肝的代谢性危险因素的差异；进一步采用多因素Logistic回归分析方法预测不同的危险因素发生亚临床甲减合并脂肪肝的概率。 结果 体检人群亚临床甲减组在收缩压、舒张压、体重指数、甘油三酯、总胆固醇、低密度脂蛋白胆固醇、尿酸7项均值高于非亚临床甲减组，差异有统计学意义（P0.05）；单因素分析结果发现，亚临床甲减合并脂肪肝者在年龄、体重、体重指数、甘油三酯、高密度脂蛋白胆固醇、尿酸6项指标与未合并脂肪肝者相比，差异有统计学意义（P0.05）；多因素Logistic回归分析结果发现，年龄[OR（95%CI）=1.13（1.00，1.28）]、体重[OR（95%CI）=1.38（0.72，2.65）]、甘油三酯[OR（95%CI）=5.78（1.87，17.92）]3项危险因素进入回归方程（P0.05）。 结论 症状隐匿的亚临床甲减合并脂肪肝有增多趋势，亚临床甲减者面临包括增龄、超重及多个心血管代谢性风险因素，在亚临床甲减合并脂肪肝的慢病管理策略中需重点解决减重、调脂、控制尿酸问题。 　　[关键词] 亚临床甲状腺功能减低；脂肪肝 　　[中图分类号] R581.2；R575.5 [文献标识码] B [文章编号] 1673-9701（2015）09-0056-04 　　An analysis on metabolic risk factors of subclinical hypothyroidism complicated with fatty liver 　　XU Weina1 ZHANG Xiaofeng2 HU Zhihong3 　　1.Zhejiang Chinese Medical University Hangzhou Wuyunshan Nursing Home in Zhejiang Province， Hangzhou 310008， China； 2.Department of Gastroenterology， Hangzhou First Peoples Hospital in Zhejiang Province， Hangzhou 310006， China； 3.Xiaoying Community Health Service Centre of Shangcheng District， Hangzhou 310000， China 　　[Abstract] Objective To explore the detection rate and metabolic risk factors of subclinical hypothyroidism complicated with fatty liver. Methods A retrospective investigation was carried out for the data of health examination in 2013， and metabolic risk factors were compared between subclinical hypothyroidism and non-subclinical hypothyroidism via the case-control study method； the single-factor t-test was applied to analyze the differences of metabolic risk factors between subclinical hypothyroidism group complicated with fatty liver and the group not complicated with fatty liver； the multi-factor Logistic regression was further applied to predict the incidence of subclinical hypothyroidism combined with fatty liver caused by different risk factors. Results Among people taking physical examination， average levels of 7 indices in subc