亚临床甲状腺功能减退症与2型糖尿病肾病关系研究.docVIP

亚临床甲状腺功能减退症与2型糖尿病肾病的关系研究 　　摘要：目的 探讨亚临床甲状腺功能减退症与2型糖尿病肾病之间的关系。方法 回顾性分析我院内分泌科 2015年1月～2017年1月收治的1376例 2 型糖尿病患者的病历资料。比较亚临床甲状腺功能减退组与甲状腺功能正常组之间糖尿病肾病的患病率。结果 1376例 2 型糖尿病患者中，有 159 例（11.50%）患者存在亚临床甲减。亚临床甲减组与甲状腺功能正常组之间糖尿病肾病的患病率无统计学差异（P0.05）；但在亚组分析中，重度的亚临床甲减组（TSH≥10 mU/L）中糖尿病肾病的患病率显著高于轻度亚临床甲减组（TSH 在 0.35～9.99 mU/L）（P0.05）。结论 在2型糖尿病患者中，糖尿病肾病的患病风险在重度亚临床甲减人群中高于甲状腺功能正常及轻度的亚临床甲减人群。 　　关键词： 2 型糖尿病；亚临床甲状腺功能减退症；糖尿病肾病 　　中图分类号：R581.2；R587.1 文献标识码：A 文章编号：1006-1959（2017）23-0033-02 　　Study on the Relationship between Subclinical Hypothyroidism and Type 2 Diabetic Nephropathy 　　GAO Hai-bo，，ZHANG Ya-wei，XIE Yong-li，GONG Yu-ping，LAI Qing-zhou，SU Xiao-qing 　　（Department of Endocrinology，Pingxiang Peoples Hospital，Pingxiang 337000，Jiangxi，China） 　　Abstract：Objective To investigate the relationship between subclinical hypothyroidism in patients with type 2 diabetic nephropathy.Methods Retrospective analysis of 1376 patients with type 2 diabetes mellitus Department of endocrinology in our hospital from January 2015 to January 2017. Compared the prevalence of subclinical hypothyroidism group and normal thyroid function group diabetic nephropathy.Results 1376 cases of type 2 diabetes mellitus patients，159 cases（11.50%）patients with subclinical hypothyroidism.Between subclinical hypothyroidism and normal thyroid function group the prevalence of diabetic nephropathy was no statistically significant difference（P0.05）；but in subgroup analysis，severe subclinical hypothyroidism group（TSH≥10 mU/L）prevalence rate in diabetic nephropathy significantly higher than mild subclinical hypothyroidism group（TSH 0.35～9.99 mU/L）（P0.05）.Conclusion In patients with type 2 diabetes mellitus，diabetic nephropathy risk in severe subclinical hypothyroidism in the population is higher than the normal thyroid function and mild subclinical hypothyroidism population. 　　Key words：Type 2 diabetes mellitus；Subclinical hypothyroidism；Diabetic nephropathy 　　甲?钕偌膊∮?2型糖尿病都是临床常见内分泌疾病[1-2]。亚临床甲状腺功能能减退症是指血清促甲状腺激素（TSH）升高，同时血清甲状腺