包皮环切术在防治夫妻共患高危型人乳头瘤病毒感染中作用.docVIP

包皮环切术在防治夫妻共患高危型人乳头瘤病毒感染中作用 　　[摘要] 目的 探讨包皮环切术在防治夫妻共患高危型人乳头瘤病毒（HPV）感染中的作用。 方法 选择2012年1月～2014年12月于华北石油管理局总医院就诊的120对夫妻，经检测夫妻双方均为高危型HPV感染，且男方均患有包皮过长。56对男性行包皮环切术的夫妻为手术组，64对男性未行包皮环切术的夫妻为对照组，1年后复查HPV感染情况。 结果 两组夫妻入组时高危型HPV的感染状况差异无统计学意义（P 0.05）。1年后复测，男性转阴率手术组为41.1%（23/56），对照组为21.9%（14/64），差异有统计学意义（P 0.05）；女性转阴率手术组37.5%（21/56），对照组20.3%（13/64），组间差异有统计学意义（P 0.05）。夫妻共同转阴率手术组23.2%（13/56），对照组6.3%（4/64），组间差异有统计学意义（P 0.05）。 结论 男性包皮环切术是减少男性自身和其配偶高危型HPV患病率和发病率的有效措施，在防治女性高危型HPV感染相关癌症中具有一定的作用。 　　[关键词] 人乳头瘤病毒；包皮环切术；病毒清除；基因检测 　　[中图分类号] R697 [文献标识码] A [文章编号] 1673-7210（2016）06（a）-0038-04 　　[Abstract] Objective To explore the effect of circumcision on preventing high-risk human papilloma virus （HPV） in concordance infection couples. Methods The subjects were 120 married couples diagnosed and treated in General Hospital of Huabei Petroleum from January 2012 to December 2014. All the couples were confirmed high-risk HPV concordance infection and husbands suffering from redundant prepuce. 56 couples with circumcised men were as surgery group， and 64 couples with uncircumcised were as control group. The couples infection were detected again after 1 year. Results The rate of high-risk HPV infection was in two groups were compared， the difference was not statistically significant （P 0.05）. After 1 year， the HR-HPV clearance rate of male in surgery group was 41.1% （23/56） and that in control group was 21.9% （14/64）， the difference was statistically significant （P 0.05）. Meanwhile this of famale in surgery group was 37.5% （21/56） that in control group was 20.3% （13/64）， the difference was statistically significant （P 0.05）. And HR-HPV clearance rate of couples in surgery group was 23.2% （13/56）， that in control group was， the difference was statistically significant （P 0.05）. Conclusion Male circumcision is a effective measure to reduce the prevalence and incidence of high-risk HPV in men and their wives. It may play a role in the prevention and treatment of cancer related with high-risk