实时动态血糖监测对早期2型糖尿病肾病低血糖干预研究.docVIP

实时动态血糖监测对早期2型糖尿病肾病低血糖干预研究 　　[摘要] 目的 以回?式动态血糖监测（CGMS）为对照，评估实时动态血糖监测对早期2型糖尿病肾病患者低血糖的干预作用。 方法 方便选取2015年10月―2016年8月在该院内分泌科住院的HbA1c在8%～11%的100例早期2型糖尿病肾病（DN）患者随机分为回顾式动态血糖监测组（回顾组）及实时动态血糖监测组（实时组）各50例。观察两组一般临床资料，比较两组平均血糖（MBG）、低血糖发生率（严重、夜间、无症状性低血糖），低血糖持续时间（严重、夜间、无症状性低血糖）。 结果 ①回顾组和实时组平均血糖[（12.0±2.5）mmol/L vs （10.8±2.3）mmol/L]，差异无统计学意义（P0.05）。②回顾组和实时组低血糖发生率（46% vs 40%）、严重低血糖发生率（12% vs 8%），差异均无统计学意义（P0.05）；夜间低血糖发生率（40% vs 24%）、无症状性低血糖发生率（22% vs 12%），差异有统计学意义（P0.05）。结论 与传统的回顾式动态血糖监测系统相比，实时动态血糖监测干预早期2型糖尿病肾病患者低血糖的发生率和持续时间，尤其在降低夜间及无症状性低血糖方面具有优势。 　　[关键词] 实时动态血糖监测；早期2型糖尿病肾病；低血糖 　　[中图分类号] R581 [文献标识码] A [文章编号] 1674-0742（2017）12（a）-0083-04 　　[Abstract] Objective To evaluate the intervention of real- time dynamic blood glucose monitoring in hypoglycemia of early type 2 diabetic nephropathy， Methods 100 cases of DN patients whose HbA1c was between 8%～11% hospitalized in our hospital from October 2015 to August 2016 were convenient selected and divided into two groups with 50 cases in each， including the dynamic blood glucose monitoring group （review group） and real-time dynamic blood glucose monitoring group（real-time group）， and the general clinical data were observed and the MBG， incidence rate of hypoglycemia（severe， night and asymptomatic hypoglycemia） duration of hypoglycemia（severe， night and asymptomatic hypoglycemia） were compared between the two groups. Results The difference in the average blood glucose between the review group and the real-time group was not statistically significant[（12.0±2.5） mmol/L vs （10.8±2.3）mmol/L]（P0.05）， and the differences in the incidence rates of hypoglycemia and severe hypoglycemia between the review group and real-time group （46% vs 40%， 12% vs 8%）， were not statistically significant（P0.05）， and the differences in the incidence rates of night hypoglycemia and asymptomatic hypoglycemia between the two groups were statistically significant（40% vs 24%， 22% vs 12%）（P0.05）. Conclusion The incidence rate of hypoglycemia and duration of real-time dy