(S)-5-羟甲基二氢呋喃-2-酮的合成与表征应用化学专业论文.docxVIP

成都理工大学硕士学位论文 成都理工大学硕士学位论文 nts,the way to add reaction substrate and the reaction temperature were furthe r studied to discuss the influence of the factors mentioned aboved on the pro ductivity which in turn determine the optimal reaction conditions. Column chro matography separation technique was used to purify products, making the yield reached 78.9%. The synthetic route has fewer side reactions and higher yield. To realize our aim synthesizing the (S)-5-(hydroxymethyl)dihydrofuran-2 (3H)-one by reduction reaction step by step, (S) -5 - oxo-tetrahydrofuran -2 - f ormic acid was used in synthesis processes through esterification, sodium boro hydride reduction substeps. Influences of ratio of, the raw material reaction tim e, reaction temperature, pH, and other conditions on the yield were evaluated. While, the yield was 58.0% using the column chromatography purification tech niques. The synthtic route characterized by the mild reaction condition and th e simple operation processes. . Two methods were compared in this paper, the total yield of direct reducti on and step by step reduction was 60.1% and 44.2% respectivel.It is concluded by the experiment that the total yield of step by step reduction, are much low er than the direct reduction which has less reaction steps, and fewer by-produ cts.So, direct reduction method is preferred under manipulated conditions in th e laboratory Keywords: L- glutamic acid (S)-5-oxotetrahydrofuran-2-carboxylic acid (S)-5-(hydroxymethyl)dihydrofuran-2(3H)-one reduction method Synthesis IV 独创性声明 本人声明所呈交的学位论文是本人在导师指导下进行的研究工作及取得的 研究成果。据我所知，除了文中特别加以标注和致谢的地方外，论文中不包含其 他人已经发表或撰写过的研究成果，也不包含为获得 成都理工大学 或其他教 育机构的学位或证书而使用过的材料。与我一同工作的人员对本研究所做的任何 贡献均已在论文中作了明确的说明并表示谢意。 学位论文作者签名：  年 月 日 学位论文版权使用授权书 本学位论文作者完全了解 成都理工大学 有关保留、使用学位论文的规定， 有权保留并向国家有关部门或机构送交论文的复印件和磁盘，允许论文被查阅和 借阅。本人授权 成都理工大学 可以将学位论文的全部或部分内容编入有关数 据库进行检索，可以采用影印、缩印或扫描等复制手段保存、汇编学位论文。 （保密的学位论文在解密后适用本授权书） 学位论文作者签名： 学