小剂量阿奇霉素对反复性支气管炎患儿外周血T淋巴细胞亚群水平影响.docVIP

小剂量阿奇霉素对反复性支气管炎患儿外周血T淋巴细胞亚群水平影响 　　[摘要] 目的 探讨对反复性支气管炎患儿给予小剂量阿奇霉素治疗后外周血T淋巴细胞亚群水平的影响。 方法 以随机综合序贯法将114例反复性支气管炎患儿分为参考组（n=57）和研究组（n=57）。两组的治疗方案分别为常规疗法、小剂量阿奇霉素联合常规疗法。对比治疗前后外周血T淋巴细胞亚群（CD3+、CD4+、CD8+、CD4+/CD8+）水平，统计临床疗效及安全性。 结果 治疗后研究组与参考组CD3+、CD4+、CD4+/CD8+均升高，且研究组均高于参考组，而两组CD8+均降低，且研究组低于参考组，T淋巴细胞亚群指标水平本组内治疗前后和治疗后组间的差异均有统计学意义（P0.05）。 结论 对反复性支气管炎患儿给予小剂量阿奇霉素能够提高CD3+、CD4+、CD4+/CD8+水平，降低CD8+水平，增强细胞免疫功能，并且不会显著增加不良反应。 　　[关键词] 阿奇霉素；反复性支气管炎；T淋巴细胞亚群；不良反应 　　[中图分类号] R725.6 [文献标识码] B [文章编号] 1673-9701（2017）35-0043-03 　　[Abstract] Objective To investigate the effect of low dose azithromycin on the level of peripheral blood T lymphocyte subsets in children patients with recurrent bronchitis. Methods 114 children patients with recurrent bronchitis who were randomLy divided into two groups： the reference group（n=57） and the study group（n=57） by random integrated sequential method. The two groups of treatment options were routine therapy， low-dose azithromycin combined with routine therapy. The levels of peripheral blood T lymphocyte subsets（CD3+， CD4+， CD8+， CD4+/CD8+） before and after the treatment were compared， and the clinical efficacy and safety were statistically analyzed. Results After treatment， the levels of CD3+， CD4+， CD4+/CD8+ in the study group and reference group were both higher， and the study group was higher than the reference group， while the level of CD8+ was lower in both group， and the study group was lower than the reference group. The differences of the levels of T lymphocyte subsets indices in this group before and after treatment and the differences between the two groups after treatment were statistically significant （P0.05）. Conclusion A small dose of azithromycin in the children patients with recurrent bronchitis can increase the levels of CD3+， CD4+， CD4+/CD8+， reduce the level of CD8+ and enhance the cellular immune function， yet will not significantly increase the adverse reactions. 　　[Key words] Azithromycin； Recurrent bronchitis； T lymphocyte subsets； A