干扰素联合热毒宁治疗小儿手足口病临床分析.docVIP

干扰素联合热毒宁治疗小儿手足口病临床分析 　　[摘要] 目的 探析干扰素雾化联合热毒宁治疗小儿手足口病的临床效果。方法 方便选取该院2012年1月―2016年12月收治的60例小儿手足口病患儿，将其随机分为治疗组和对照组，各30例，对照组单纯以热毒宁治疗，治疗组在此基础上联合干扰素雾化治疗，比较两组治疗效果、症状消失时间及治疗前后心肌酶谱及ALT水平。结果 治疗组总有效率97.67%与对照组76.67%比较差异有统计学意义（P0.05）；治疗组口腔溃疡消失时间（2.0±0.3）d、手足疱疹消失时间（2.4±0.4）d、体温恢复正常时间（2.3±0.1）d及住院时间（4.5±1.2）d与对照组比较差异有统计学意义（P0.05）；治疗后，治疗组ALT水平（33.2±3.4）U/L、CK（33.5±1.2）U/L、CK-MB（27.6±1.2）U/L、LDH（321.3±5.2）U/L与治疗前比较降低，与对照组比较差异有统计学意义（P0.05）。结论 干扰素雾化联合热毒宁治疗小儿手足口病的临床效果确切，值得临床推广。 　　[关键词] 干扰素；热毒宁；小儿手足口病 　　[中图分类号] R725 [文献标识码] A [文章编号] 1674-0742（2017）02（b）-0128-03 　　[Abstract] Objective To discuss the clinical effect of interferon and reduning injection in treatment of pediatric foot and mouth disease. Methods Convenient selection 60 cases of children with foot and mouth disease admitted and treated in our hospital from January 2012 to December 2016 were selected and randomly divided into two groups with 30 cases in each， the control group were treated with simple reduning injection， while the treatment group adopted the interferon and reduning injection， and the treatment effect， symptom disappearance time and cardiac creatase and ALT level before and after treatment were compared between the two groups. Results The difference in the total effective rate between the treatment group and the control group had statistical significance（97.67% vs 76.67%）（P0.05）and the dental ulcer disappearance time， rashes on hands and feet disappearance time， body temperature recovery normal time and length of stay in the treatment group were respectively （2.0±0.3）， （2.4±0.4）， （2.3±0.1）d and （4.5±1.2）d， and the difference between the two groups had statistical significance（P0.05）， after treatment， the ALT level，CK， CK-MB， and LDH were respectively（33.2±3.4），（33.5±1.2），（27.6±1.2）U/L and（321.3±5.2）U/L， which decreased compared with those before treatment， and the difference between the two groups had statistical significance（P0.05）. Conclusion The clinical effect of interferon and reduning injection in tr