幽门螺杆菌在消化不良妊娠妇女中表达研究.docVIP

幽门螺杆菌在消化不良妊娠妇女中表达研究 　　【摘要】 目的：研究幽门螺杆菌（Hp）在消化不良妊娠妇女中的表达，探讨Hp感染与消化不良的相关性。方法：将本院2012年3月-2013年9月接诊的90例消化不良妊娠孕妇作为研究对象，另选取同期90例无消化不良症状和胃肠道疾病史的妊娠妇女作为对照组。对两组妊娠妇女Hp和CagA的情况进行分析。结果：Hp血清阳性检出率在消化不良组中略高于对照组，但差异无统计学意义（68%vs 59%，P0.05）。在Hp阳性的病例中有消化道症状和无消化道症状两组的CagA阳性率差异有统计学意义（62%vs 43%，P=0.0002）。结论：在消化不良的妊娠妇女中，Hp感染增高，但差异无统计学意义， CagA血清阳性者中消化不良的发病率显著高于CagA阴性者，由此可见，高致病性Hp菌株与妊娠妇女消化不良密切相关。临床治疗，应将Hp菌株的清除作为切入点，通过清除Hp菌株，减轻消化不良的症状。 　　【关键词】 幽门螺杆菌； 细胞毒素相关基因A； 妊娠； 消化不良 　　【Abstract】 Objective：To study the expression of helicobacter pylori in indigestion pregnant women，investigate the relationship between helicobacter pylori infection and indigestion.Method：From March 2012 to September 2013 alone， 90 cases of indigestion pregnancy pregnant women were selected as the research object， the selection over the same period 90 cases with no history of digestive symptoms and gastrointestinal disease pregnant women as control group.Hp and CagA in two groups was analyzed.Result：The positive serum of H.pylori was slightly higher than the control group in the indigestion group but there was no significant difference （68% vs59 %，P0.05）.In H.pylori positive cases with gastrointestinal symptoms and no digestive tract symptoms in the two groups of CagA positive rate had significant difference （vs43%62%，P=0.0002）.Conclusion：In the pregnant women of indigestion，increased Hp infection is not statistically difference， however， the incidence of indigestion in cagA positive serum was significantly higher than that of cagA negatie， thus， highly pathogenic Hp strains is closely related to the pregnant women indigestion.Clinical treatment，Hp strains should be clear as a breakthrough point，through clearing Hp strains， relieve the symptoms of indigestion. 　　【Key words】 Helicobacter pylori； CagA； Pregnant； Indigestion 　　消化不良是妊娠期常见的症状，消化不良是描述一组症状的术语，往往是与饮食有关，包括上腹疼痛、腹胀、消化不良、饱胀、恶心、胃灼热、恶心、呕吐等多种症状。在正常人群中很多研究证实CagA阳性的高致病性幽门螺杆菌（Helicobacter pylori， Hp）感染和非溃疡性消化不良相关，现认为妊娠剧吐可能和感染Hp有关[2]，但对于妊娠妇女这方面的研究很少。在本文中，笔者将本院2012年3月-2013