不同糖代谢状态血清25-(OH)VitD3、Betatrophin水平及相关研究-内科学(内分泌与代谢病学)专业论文.docxVIP

中文摘要 不同糖代谢状态血清 25-(OH)VitD3、Betatrophin 水平及相关研究 素相关分析显示血清 25-(OH)VitD3 水平与体脂百分比、去脂体质量、骨 骼肌含量、右上肢肌肉含量、躯干肌肉含量、双下肢肌肉含量显著相关 （P 均＜0.05），与 HOMA-IR、HOMA-β、血糖及血脂等无明显相关性。 新诊断 2 型糖尿病血清 betatrophin 与去脂体质量、骨骼肌含量、右上肢 肌肉含量、躯干肌肉含量、双下肢肌肉含量显著相关（P 均＜0.05），在 糖耐量正常及全部人群，血清 betatrophin 与 HOMA-β 相关。Logistic 回 归分析示体脂百分比、躯干肌肉含量是预测血清 25-(OH)VitD3 缺乏的独 立影响因子。 结论：新诊断 2 型糖尿病血清 25-(OH)VitD3 水平低于糖耐量正常者， 血清 25-(OH)VitD3 与血糖、血脂、HOMA-IR、HOMA-β 及骨密度无明显 相关性，体脂百分比、肌肉含量影响血清 25-(OH)VitD3 水平；新诊断 2 型糖尿病组血清 betatrophin 水平明显高于糖耐量减低及糖耐量正常组， HOMA-β 明显降低，肌肉含量影响新诊断 2 型糖尿病血清 betatrophin 水 平，betatrophin 可能与胰岛 β 细胞功能有关。 关键词：糖尿病；2 型；25-(OH)VitD3；Betatrophin； 作 者：高 婷 指导老师：于雪梅 II PAGE PAGE IV 不同糖代谢状态血清 25-(OH)VitD3、Betatrophin 水平及相关研究 英文摘要 Serum 25-(OH)VitD3, betatrophin levels and the influencing factors in different glycometabolism states Abstract Objective ： Serum 25-(OH)VitD3 deficiency is common, serum betatrophin level is unclear, and serum 25-(OH)VitD3, betatrophin levels may be related to diabetes. We will observe serum 25-(OH)VitD3 and betatrophin levels in different glycometabolism states, and investigate the relationship between serum 25-(OH)VitD3, betatrophin and clinical of indicators in different glycometabolism states. Methods：A total of 460 permanent residents of Fengxian aged 40-60 years were enrolled. Questionnaire, physical examination, biochemical, serum 25-(OH)VitD3, serum betatrophin, body fat composition and bone mineral density were measured. Glucolipid metabolism, islet function, body fat composition and bone mineral density were observed in different glucose tolerance and also in people with 25-(OH)VitD3 deficiency and without 25-(OH)VitD3 deficiency. Pearson correlation coefficients were applied in analyzing the correlations between serum 25-(OH)VitD3, betatrophin and various indicators. Independent risk factors of 25-(OH)VitD3 deficiency were analyzed by Logistic regression. Results：There were 63 newly diagnosed patients with type 2 diabetes, 108 patients with pre-diabetes and 2