不同糖代谢状态血清25-(OH)D3水平变化的临床意义内分泌与代谢病专业论文.docxVIP

青海大学硕士学位论文英文 青海大学硕士学位论文 英文摘要 II II Abstract Objective: Explore the relationship between serum 25 (OH) D level with type 2 diabetes. Method: Choose healthy check-up in the same period 30 patients (NGT) for group 1, patients with abnormal glucose tolerance (IGT/IFG) 32 cases of group 2, newly diagnosed type 2 diabetes mellitus (T2DM) patients 48 cases for group 3, the treatment of type 2 diabetic patients with 50 cases of group 4, record the basic information and clinical observation clinical index. Analysis of the four groups-serum 25 (OH) D3 level and age, gender, BMI, SBP and DBP, FPG, TG, CHOL, 2 hPG, FINS, HbA1c and islet function relations. Results: 1. Between each group the BMI, TG, DBP, 25 (OH) D, FPG, 2 hPG, FINS, homa-ir, HOMA-β, HbA1c are statistically significant differences, P 0.05. Serum 25 (OH) D levels significantly reduce in sugar metabolism disorders，the difference between each group was not statistically significant. Related analysis showed that the serum 25 (OH) D level and age, BMI, FPG, P2hPG, HbA1c into negative correlation (r = -0.396, -0.229, 0.248, 0.184, 0.213, P 0.05), and HOMA-β a positive correlation (r = 0.176, P 0.05), and TG, CHOL, SBP and DBP, homa-ir, FINS have no obvious related (P 0.05). Multiple stepwise regression analysis showed that age, BMI, sex, HbA1c influence is serum 25 (OH) D level-the main factors (t = 4.271, -3.829, 4.094, 2.964, P 0.05). Conclusion: 1. Serum 25 (OH) D level is closely related to sugar metabolism condition，the lack of vitamin D may cause abnormal glucose tolerance and the rise of blood sugar levels. Long-term poor blood sugar control in the metabolic abnormalities may result in serum 25 (OH) D reduced. 2. Age, BMI, sex, HbA1c is the main influence factors of serum 25 (OH) D level. 【 key words 】 25 (OH) D3; Type 2 diabetes; Glycated hemoglobin; Islet function Paper types: applied research 青海大学硕士学位论文目录 青海大学硕士学位论文 目录 PAGE IV PAGE IV 目录 中文摘要 I HYPERLINK \l _bookmark0 ABSTRACT II HYPERLINK \l