尼莫地平治疗自发性蛛网膜下腔出血作用观察.docVIP

尼莫地平治疗自发性蛛网膜下腔出血作用观察 　　[摘要] 目的 研究尼莫地平治疗自发性蛛网膜下腔出血的临床疗效。 方法 选取2013年4月～2015年3月于我院就诊的自发性蛛网膜下腔出血患者52例，随机分为观察组（常规疗法联合尼莫地平治疗）与对照组（常规治疗）各26例，对比两组的临床治疗效果。 结果 观察组的头痛、呕吐以及意识模糊等临床症状的消失时间分别为（4.68±1.74）d、（2.14±0.55）d、（5.32±2.08）d，均低于对照组，组间对比差异显著（t=12.48，7.60，16.49；P0.05）。观察组的治疗总有效率为92.31%，显著高于对照组（x2=6.40；P0.05）；观察组的出血吸收时间与脑血管痉挛发生率分别为（6.32±1.20）d、1例（3.85%）；均显著低于对照组水平，组间差异具统计学意义（t=9.34，x2=4.12；P0.05）。 结论 应用尼莫地平治疗自发性蛛网膜下腔出血的效果优良，可促进症状改善、降低脑血管痉挛发生率，有利于病情康复，值得推广应用。 　　[关键词] 尼莫地平；自发性蛛网膜下腔出血；临床疗效 　　[中图分类号] R743.3 [文献标识码] B [文章编号] 2095-0616（2015）19-127-03 　　[Abstract] Objective To study the clinical curative effect of nimodipine in treatment of spontaneous subarachnoid hemorrhage. Methods 52 patients with spontaneous subarachnoid hemorrhage who were admitted to our hospital from April 2013 to March 2015 were selected and they were randomly divided into the observation group （routine treatment combined with nimodipine） and the control group （routine treatment）， with 26 in each. Clinical curative effects of two groups were compared. Results Disappeared time of clinical symptoms including headache， vomiting， confusion and so on of the observation group were （4.68±1.74） d， （2.14±0.55） d and （5.32±2.08） d respectively， lower than those in the control group， Differences between two groups were significant （t=12.48，7.60，16.49； P0.05）. Total effective rate of treatment in the observation group was 92.31%， significantly higher than that of the control group （x2= 6.40； P0.05）. Hemorrhage absorption time and the incidence of cerebral vasospasm of the observation group were （6.32±1.20）d and 1 case （3.85%） respectively， both significantly lower than those in the control group. Differences between two groups were statistically significant （t=9.34， x2=4.12； P0.05）. Conclusion Nimodipine in treatment of spontaneous subarachnoid hemorrhage has good curative effect. It can promote the improvement of symptoms and incidence of cerebral vasospasm which is helpful for disease rehabilitation， worthy of pr