急性ST段抬高型心肌梗死患者血浆BNP水平与心肌缺血程度相关性研究.docVIP

急性ST段抬高型心肌梗死患者血浆BNP水平与心肌缺血程度相关性研究 　　[摘要] 目的 探讨急性ST段抬高型心肌梗死患者的血浆B型脑利钠肽水平及其与心肌缺血程度的关系。 方法 选取2011年1月～2014年12月，我院收治的STEMI患者78例作为观察组，同期正常对照组78例，检测并比较各组的BNP、心肌肌钙蛋白Ⅰ（CTnⅠ）水平及Gensini积分，分析BNP与心肌缺血间的关系。 结果 观察组的BNP及CTnⅠ水平显著高于对照组（P0.05），且观察组病变支数越多，患者的BNP、CTnⅠ水平及Gensini积分越高（P0.05）；血浆BNP与Gensini积分及CTnⅠ峰值呈显著正相关性（P0.05）。 结论 STEMI患者存在BNP及CTnⅠ水平升高现象，升高程度越明显则病变越严重；BNP与心肌缺血程度密切相关，可作为早期评价病情与心肌缺血的敏感指标。 　　[关键词] ST段抬高型；急性心肌梗死；B型脑利钠肽；心肌缺血 　　[中图分类号] R542.22 [文献标识码] B [文章编号] 2095-0616（2015）16-132-04 　　Plasma BNP level and its correlation with the degree of myocardial infarction in patients with acute ST segment elevation myocardial infarction 　　WANG Peisong 　　Department of Cardiology， the Third Sanmenxia Peoples Hospital， Sanmenxia 472143， China 　　[Abstract] Objective To explore plasma b-type brain natriuretic peptide levels and its correlation with the degree of myocardial ischemia in patients with acute ST segment elevation myocardial infarction （STEMI）. Methods 78 patients with STEMI who were admitted in the third Sanmenxia peoples hospital From January to December in 2011 were selected as observation group， and 78 normal subjects were selected as control group. Levels of BNP and cardiac troponin Ⅰ （CTn Ⅰ） and the Gensini score were tested and compared between two groups. Correlation between levels of BNP and myocardial ischemia was analyzed. Results Levels of BNP and CTn Ⅰof the observation group were significantly higher than that of control group （P0.05）， whats more， in the observation group the more the affected branches were， the higher levels of BNP， CTn Ⅰand the Gensini score were （P0.05）； Plasma levels of BNP were significantly positive correlations （P0.05） with Gensini score and the peak of CTn Ⅰ. Conclusion The levels of BNP and CTn Ⅰin patients with STEMI will rise. The higher levels of those rise， the more serious lesion is. Level of BNP is closely related to the degree of myocardial ischemia， and can be used for early evaluation of disease and as a sensitive indicator