急性脑梗死患者治疗前后血浆HCYvWF和血清P选择素水平检测临床意义.docVIP

急性脑梗死患者治疗前后血浆HCYvWF和血清P选择素水平检测临床意义 　　[摘要] 目的:探讨急性脑梗死患者治疗前后血浆HCY、vWF和血清P-选择素水平的变化及临床意义。方法:应用ELISA法对32例急性脑梗死患者进行血浆HCY、vWF和血清P-选择素水平检测,并与35例正常人进行比较。结果:患者组治疗前血浆HCY、vWF和血清P-选择素水平均显著高于正常人组(P0.01),经溶栓等措施治疗1个月后与正常人比较,差异有统计学意义(P0.05)。结论:检测急性脑梗死患者治疗前后血浆HCY、vWF和血清P-选择素水平的变化对了解病情及观察疗效均具有重要的临床价值。 　　[关键词] 脑梗死;HCY;vWF;P-选择素 　　[中图分类号] R743[文献标识码]A [文章编号]1673-7210(2010)02(c)-033-02 　　 　　Clinical significance of detection of plasma HCY, vWF and serum P-selectin levels before and after treatment in patients with cerebral infarction 　　XU Bingchao, HE Mingli, XU Yingda, ZHAO Shaolin 　　(Department of Neurology, Lianyungang Hospital of Xuzhou Medical College, Lianyungang 222002, China) 　　[Abstract] Objective: To explore the clinical significance of detection of plasma homocysteine (HCY), von willebrand factor (vWF) and serum P-selectin levels before and after treatment in patients with cerebral infarction. Methods: Plasma HCY, vWF and serum P-selectin levels were determined by ELISA assay in 32 patients with cerebral infarction and 35 normal people. Results: Before treatment, the plasma HCY, vWF and serum P-selectin levels of patient group were significantly higher than those of normal people group (P0.01). One month after treatment, plasma HCY, vWF and serum P-selectin levels were also higher than those of normal people group (P0.05). Conclusion: Detection of plasma HCY, vWF and serum P-selectin before and after treatment is important for understanding the pathogenetic condition and observing efficacy of patients with cerebral infarction. 　　[Key words] Cerebral infarction; HCY; vWF; P-selectin 　　 　　急性脑梗死患者常伴有纤溶系统功能失调或障碍,易发生血液学的多种改变。为了解急性脑梗死患者血浆HCY、vWF和血清P-选择素水平的变化,笔者用ELISA法测定32例急性脑梗死患者治疗前后血浆HCY、vWF和血清P-选择素水平的变化,探讨急性脑梗死患者治疗前后血浆HCY、vWF和血清P-选择素水平的变化及临床意义。 　　1 资料与方法 　　1.1 一般资料 　　1.1.1患者组32例,其中,男22例,女10例,均为我院神经内科经临床明确诊断的急性脑梗死患者,检查项目包括症状、体征、CT或MRI及实验室有关指标。 　　1.1.2 正常人组35例,其中,男25例,女10例,均为我院体检中心经健康体检合格的正常人,无心、肝、肺、肾等主要脏器疾病。肝、肾功能检查结果正常,无心、脑血管病史。 　　1.2方法 　　1.2.1血浆HCY、vWF水平测定用真空负压管