急性脑梗死患者血浆内皮素1变化及其相关因素分析.docVIP

急性脑梗死患者血浆内皮素1变化及其相关因素分析 　　中图分类号：R743.3 文献标识 码：A 文章编号：1009_816X(2010)02_0093_02 　　The Plasma Endothelin_1 Level in Acute Cerebral Infarction and its R elationship with Stroke Risk Factors. ZHOU Zhi_bin, YU Yong_jie,ZHU Zheng_fang, et al. De partment of Neurology, The Peoples Hospital of Quzhou kecheng, Zhejiang 324000 , ?China 　　［Abstract］ ObjectiveTo observe the relationship between plasma content of endot helin_1(ET_1) and its risk factors in patients with acute cerebral infarction (A CI). MethodsThe levels of plasma ET_1, serum cholesterol, triglyceride, low den sity lipoprotein, high density lipoprotein and blood sugar were measured in 120patients with ACI (within 72 hours of onset) and 84 normal healthy subjects. TheEuropean Stroke Scale (ESS) was used to evaluate neurological deficit for ACI p atients.ResultsACI patients had significantly higher level of plasma ET_1 com pared with normal control subjects ［(183.27±56.63)pg/ml versus(156.47±34. 24)pg/ml, P＜0.05］, but there was no correlation between plasma ET_1 conce ntration an d hypertension, diabetes mellitus, serum cholesterol, triglyceride, low densitylipoprotein, high density lipoprotein or ESS(all P＞0.05).ConclusionsIncreased ET_1 level in plasma in early stage of ACI suggests that it may be inv olved inthe development of cerebral infarction. But the relationship between plasma ET_ 1 and common ischemic stroke risk factors is still unclear. 　　［Key words］ Endothelin; Cerebral infarction; Stroke risk facto r 　　 　　 血浆内皮素(ET)是血管内皮分泌的一种缩血管活性因子，ET在缺血性脑血管病的发生、发展 中起重要作用［1～3］。ET有三种异构体：ET_1、ET_2和ET_3，其中ET_1收缩血管作 用最强、效应最持久，监测血浆ET_1能帮助判断病情变化和评估预后。本文 对急性脑梗死(ACI)患者血浆ET_1的改变及其与卒中常见危险因素的关系进行观察，探讨ET_ 1在ACI发病机制中的作用。 　　 　　1 资料与方法 　　 　　1.1 一般资料：ACI组：本组为2005年2月至2008年5月在我科住院的急性脑梗死患者，共1 20例，男75例，女45例；年龄50～83(平均66.30±8.49)岁；有高血压史96例，糖尿 病史27例，卒中史42例(包括2次以上卒中史15例)。急性脑梗死的诊断依据全国第四届脑血 管病会议修订的标准，并全部经头颅CT或/和MRI证实，且均在发病72小时内入院。梗死病灶 部位：基底节区33例，放射冠区22例，脑叶21例，丘脑13例，脑干5例，小脑7例，多发性梗 死19例。对照组：为同期健康体检居民，无心、肝、肾及血栓性疾病，无高血压、冠心病、 糖尿病及卒中史，